Cell Biology Antibodies 8
Anti-GDF3 Antibody (CAB2738)
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- SKU:
- CAB2738
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GDF3 Antibody |
| Antibody SKU: | CAB2738 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-364 of human GDF3 (NP_065685.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-364 of human GDF3 (NP_065685.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AAIP VPKL SCKN LCHR HQLF INFR DLGW HKWI IAPK GFMA NYCH GECP FSLT ISLN SSNY AFMQ ALMH AVDP EIPQ AVCI PTKL SPIS MLYQ DNND NVIL RHYE DMVV DECG CG |
| Gene ID: | 9573 |
| Uniprot: | Q9NR23 |
| Cellular Location: | Secreted |
| Calculated MW: | 41kDa |
| Observed MW: | 44kDa |
| Synonyms: | GDF3, KFS3, MCOP7, MCOPCB6 |
| Background: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. |
| UniProt Protein Function: | GDF3: Defects in GDF3 are the cause of Klippel-Feil syndrome type 3 (KFS3); also called Klippel-Feil syndrome autosomal dominant 3. KFS3 is a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Defects in GDF3 are the cause of microphthalmia isolated with coloboma type 6 (MCOPCB6); also called isolated colobomatous microphthalmia 6. MCOPCB6 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Defects in GDF3 are a cause of microphthalmia isolated type 7 (MCOP7). MCOP7 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted Chromosomal Location of Human Ortholog: 12p13.1 Cellular Component: cytoplasm; extracellular space Molecular Function:cytokine activity; protein kinase binding; transforming growth factor beta receptor binding Biological Process: cell development; eye development; negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; regulation of apoptosis; regulation of cell fate commitment; regulation of MAPKKK cascade; skeletal development Disease: Klippel-feil Syndrome 3, Autosomal Dominant; Microphthalmia, Isolated 7; Microphthalmia, Isolated, With Coloboma 6 |
| NCBI Summary: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NR23 |
| NCBI GenInfo Identifier: | 46397885 |
| NCBI Gene ID: | 9573 |
| NCBI Accession: | Q9NR23.3 |
| UniProt Secondary Accession: | Q9NR23,Q8NEJ4, |
| UniProt Related Accession: | Q9NR23 |
| Molecular Weight: | 41,387 Da |
| NCBI Full Name: | Growth/differentiation factor 3 |
| NCBI Synonym Full Names: | growth differentiation factor 3 |
| NCBI Official Symbol: | GDF3 |
| NCBI Official Synonym Symbols: | KFS3; MCOP7; MCOPCB6 |
| NCBI Protein Information: | growth/differentiation factor 3 |
| UniProt Protein Name: | Growth/differentiation factor 3 |
| Protein Family: | Growth/differentiation factor |
| UniProt Gene Name: | GDF3 |
| UniProt Entry Name: | GDF3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GDF3 antibody (CAB2738) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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