Cell Biology Antibodies 10

Anti-GCNT2 Antibody (CAB6600)

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SKU:
CAB6600
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GCNT2 Antibody
Antibody SKU:CAB6600
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 203-402 of human GCNT2 (NP_663630.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 203-402 of human GCNT2 (NP_663630.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IVQH LKGF KGKN ITPG VLPP DHAI KRTK YVHQ EHTD KGGF FVKN TNIL KTSP PHQL TIYF GTAY VALT RDFV DFVL RDQR AIDL LQWS KDTY SPDE HFWV TLNR VSGV PGSM PNAS WTGN LRAI KWSD MEDR HGGC HGHY VHGI CIYG NGDL KWLV NSPS LFAN KFEL NTYP LTVE CLEL RHRE RTLN QSET AIQP SWYF
Gene ID:2651
Uniprot:Q8N0V5
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:45kDa/46kDa
Observed MW:Refer to figures
Synonyms:GCNT2, CCAT, CTRCT13, GCNT2C, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3, bA360O19.2, bA421M1.1
Background:This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1, 6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:GCNT2: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 2.4.1.150

Chromosomal Location of Human Ortholog: 6p24.2

Molecular Function:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process: positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein kinase B signaling cascade; protein amino acid glycosylation; transforming growth factor beta receptor signaling pathway

Disease: Blood Group, I System

NCBI Summary:This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N0V5
NCBI GenInfo Identifier:74714686
NCBI Gene ID:2651
NCBI Accession:Q8N0V5.1
UniProt Secondary Accession:Q8N0V5,Q06430, Q5T4J1, Q5W0E9, Q6T5E5, Q8NFS9,
UniProt Related Accession:Q8N0V5
Molecular Weight:46,531 Da
NCBI Full Name:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
NCBI Synonym Full Names:glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
NCBI Official Symbol:GCNT2  
NCBI Official Synonym Symbols:II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2  
NCBI Protein Information:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Protein Name:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Synonym Protein Names:I-branching enzyme; IGNT
Protein Family:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Gene Name:GCNT2  
UniProt Entry Name:GNT2A_HUMAN
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