Immunology Antibodies 3

Anti-GCN2 Antibody (CAB2307)

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SKU:
CAB2307
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-GCN2 Antibody
Antibody SKU:CAB2307
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GCN2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, U-87MG
Immunogen:A synthesized peptide derived from human GCN2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:440275
Uniprot:Q9P2K8
Cellular Location:
Calculated MW:187kDa
Observed MW:220KDa
Synonyms:GCN2, PVOD2
Background:This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
UniProt Protein Function:GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Translation; Other group; PEK family; GCN2 subfamily

Chromosomal Location of Human Ortholog: 15q15.1

Molecular Function:protein serine/threonine kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding

Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive

NCBI Summary:This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
UniProt Code:Q9P2K8
NCBI GenInfo Identifier:296439368
NCBI Gene ID:440275
NCBI Accession:Q9P2K8.3
UniProt Secondary Accession:Q9P2K8,Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5 Q9UJ56, C9JEC4,
UniProt Related Accession:Q9P2K8
Molecular Weight:
NCBI Full Name:Eukaryotic translation initiation factor 2-alpha kinase 4
NCBI Synonym Full Names:eukaryotic translation initiation factor 2 alpha kinase 4
NCBI Official Symbol:EIF2AK4  
NCBI Official Synonym Symbols:GCN2; PVOD2  
NCBI Protein Information:eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase; general control nonderepressible 2
UniProt Protein Name:Eukaryotic translation initiation factor 2-alpha kinase 4
UniProt Synonym Protein Names:GCN2-like protein
UniProt Gene Name:EIF2AK4  
UniProt Entry Name:E2AK4_HUMAN
Anti-GCN2 Antibody (CAB2307)Western blot - GCN2 Rabbit mAb (CAB2307)
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