Epigenetics & Nuclear Signaling Antibodies 4

Anti-GCM1 Antibody (CAB7282)

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SKU:
CAB7282
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-GCM1 Antibody
Antibody SKU:CAB7282
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human GCM1 (NP_003634.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SFQE GVQL PGSY SGHL IANT PQQN SLND CFSF SKSY GLGG ITDL TDQT STVD PMKL YEKR KLSS SRTY SSGD LLPP SASG VYSD HGDL QAWS KNAA LGRN HLAD NCYS NYPF PLTS WPCS FSPS QNSS EPFY QQLP LEPP AAKT GCPP LWPN PAGN LYEE KVHV DFNS YVQS PAYH SPQE DPFL FTYA SHPH QQYS LPSK SSKW DFEE EMTY LGLD HCNN DMLL NLCP LR
Gene ID:8521
Uniprot:Q9NP62
Cellular Location:Nucleus
Calculated MW:49kDa
Observed MW:Refer to figures
Synonyms:GCM1, GCMA, hGCMa
Background:This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.
UniProt Protein Function:GCM1: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: transcription factor complex; nucleus

Molecular Function:protein binding; DNA binding; zinc ion binding; histone deacetylase binding; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of syncytium formation by plasma membrane fusion; anatomical structure morphogenesis; regulation of transcription, DNA-dependent; astrocyte fate commitment; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NP62
NCBI GenInfo Identifier:33516903
NCBI Gene ID:8521
NCBI Accession:Q9NP62.1
UniProt Secondary Accession:Q9NP62,Q4VAQ7, Q5T0X0, Q99468, Q9P1X3,
UniProt Related Accession:Q9NP62
Molecular Weight:49,268 Da
NCBI Full Name:Chorion-specific transcription factor GCMa
NCBI Synonym Full Names:glial cells missing homolog 1 (Drosophila)
NCBI Official Symbol:GCM1  
NCBI Official Synonym Symbols:GCMA; hGCMa  
NCBI Protein Information:chorion-specific transcription factor GCMa; GCM motif protein 1
UniProt Protein Name:Chorion-specific transcription factor GCMa
UniProt Synonym Protein Names:GCM motif protein 1; Glial cells missing homolog 1
Protein Family:Chorion-specific transcription factor
UniProt Gene Name:GCM1  
UniProt Entry Name:GCM1_HUMAN
Anti-GCM1 Antibody (CAB7282)Immunofluorescence analysis of MCF-7 cells using GCM1 antibody (CAB7282). Blue: DAPI for nuclear staining.
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