Metabolism Antibodies 3

Anti-GCLM Antibody (CAB11444)

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SKU:
CAB11444
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-GCLM Antibody
Antibody SKU:CAB11444
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GCLM
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U2OS, HeLa, A-431
Immunogen:A synthesized peptide derived from human GCLM
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2730
Uniprot:P48507
Cellular Location:
Calculated MW:31kDa
Observed MW:30kd
Anti-GCLM AntibodyWestern blot - GCLM Rabbit mAb (CAB11444)
Synonyms:GLCLR
Background:Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
UniProt Protein Function:GCLM: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 1p22.1

Cellular Component: cytosol; glutamate-cysteine ligase complex

Molecular Function:enzyme regulator activity; glutamate-cysteine ligase activity; glutamate-cysteine ligase catalytic subunit binding

Biological Process: glutamate metabolic process; glutathione biosynthetic process; positive regulation of glutamate-cysteine ligase activity; regulation of blood vessel size; response to drug; response to oxidative stress; sulfur amino acid metabolic process

Disease: Myocardial Infarction, Susceptibility To

NCBI Summary:Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
UniProt Code:P48507
NCBI GenInfo Identifier:1346188
NCBI Gene ID:2730
NCBI Accession:P48507.1
UniProt Secondary Accession:P48507,Q6FHC1, Q9NPX9, Q9NU74, A8K334, D3DT45, M5A959
UniProt Related Accession:P48507
Molecular Weight:28,135 Da
NCBI Full Name:Glutamate--cysteine ligase regulatory subunit
NCBI Synonym Full Names:glutamate-cysteine ligase modifier subunit
NCBI Official Symbol:GCLM  
NCBI Official Synonym Symbols:GLCLR  
NCBI Protein Information:glutamate--cysteine ligase regulatory subunit
UniProt Protein Name:Glutamate--cysteine ligase regulatory subunit
UniProt Synonym Protein Names:GCS light chain; Gamma-ECS regulatory subunit; Gamma-glutamylcysteine synthetase regulatory subunit; Glutamate--cysteine ligase modifier subunit
Protein Family:Glutamate--cysteine ligase regulatory
UniProt Gene Name:GCLM  
UniProt Entry Name:GSH0_HUMAN
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