Metabolism Antibodies 3
Anti-GCLC Antibody (CAB4499)
- SKU:
- CAB4499
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GCL
- Synonyms:
- GCS
- Synonyms:
- GLCL
- Synonyms:
- GLCLC
- Research Area:
- Metabolism
Description
| Product Name: | GCLC Rabbit mAb |
| Product Code: | CAB4499 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GCL, GCS, GLCL, GLCLC |
| Applications: | WB, IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GCLC |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, HepG2, Rat kidney |
| Immunogen: | A synthesized peptide derived from human GCLC |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2729 |
| Uniprot: | P48506 |
| Calculated MW: | 73kDa |
| Observed MW: | 73KDa |
| UniProt Protein Function: | GCLC: Defects in GCLC are the cause of hemolytic anemia (HAGGSD). Belongs to the glutamate--cysteine ligase type 3 family. |
| UniProt Protein Details: | Protein type:Ligase; Other Amino Acids Metabolism - glutathione; EC 6.3.2.2 Chromosomal Location of Human Ortholog: 6p12 Cellular Component: glutamate-cysteine ligase complex; cytosol Molecular Function:glutamate binding; protein heterodimerization activity; glutamate-cysteine ligase activity; magnesium ion binding; coenzyme binding; ADP binding; ATP binding Biological Process: glutamate metabolic process; response to arsenic; L-ascorbic acid metabolic process; response to hormone stimulus; response to nitrosative stress; cysteine metabolic process; apoptotic mitochondrial changes; sulfur amino acid metabolic process; response to heat; cell redox homeostasis; xenobiotic metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; glutathione biosynthetic process; negative regulation of protein ubiquitination; negative regulation of neuron apoptosis; response to oxidative stress; negative regulation of transcription, DNA-dependent; regulation of blood vessel size; regulation of mitochondrial depolarization; negative regulation of apoptosis Disease: Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To; Myocardial Infarction, Susceptibility To |
| NCBI Summary: | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010] |
| UniProt Code: | P48506 |
| NCBI GenInfo Identifier: | 1346190 |
| NCBI Gene ID: | 2729 |
| NCBI Accession: | P48506.2 |
| UniProt Secondary Accession: | P48506,Q14399, |
| UniProt Related Accession: | P48506 |
| Molecular Weight: | 72,766 Da |
| NCBI Full Name: | Glutamate--cysteine ligase catalytic subunit |
| NCBI Synonym Full Names: | glutamate-cysteine ligase, catalytic subunit |
| NCBI Official Symbol: | GCLC |
| NCBI Official Synonym Symbols: | GCL; GCS; GLCL; GLCLC |
| NCBI Protein Information: | glutamate--cysteine ligase catalytic subunit; gamma-ECS; GCS heavy chain; gamma-glutamylcysteine synthetase |
| UniProt Protein Name: | Glutamate--cysteine ligase catalytic subunit |
| UniProt Synonym Protein Names: | GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase |
| Protein Family: | Glutamate--cysteine ligase |
| UniProt Gene Name: | GCLC |
| UniProt Entry Name: | GSH1_HUMAN |
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