Metabolism Antibodies 3

Anti-GCLC Antibody (CAB4499)

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SKU:
CAB4499
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GCL
Synonyms:
GCS
Synonyms:
GLCL
Synonyms:
GLCLC
Research Area:
Metabolism

Description

Product Name:GCLC Rabbit mAb
Product Code:CAB4499
Size:20uL, 50uL, 100uL
Synonyms:GCL, GCS, GLCL, GLCLC
Applications:WB, IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human GCLC
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HeLa, HepG2, Rat kidney
Immunogen:A synthesized peptide derived from human GCLC
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2729
Uniprot:P48506
Calculated MW:73kDa
Observed MW:73KDa
UniProt Protein Function:GCLC: Defects in GCLC are the cause of hemolytic anemia (HAGGSD). Belongs to the glutamate--cysteine ligase type 3 family.
UniProt Protein Details:

Protein type:Ligase; Other Amino Acids Metabolism - glutathione; EC 6.3.2.2

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: glutamate-cysteine ligase complex; cytosol

Molecular Function:glutamate binding; protein heterodimerization activity; glutamate-cysteine ligase activity; magnesium ion binding; coenzyme binding; ADP binding; ATP binding

Biological Process: glutamate metabolic process; response to arsenic; L-ascorbic acid metabolic process; response to hormone stimulus; response to nitrosative stress; cysteine metabolic process; apoptotic mitochondrial changes; sulfur amino acid metabolic process; response to heat; cell redox homeostasis; xenobiotic metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; glutathione biosynthetic process; negative regulation of protein ubiquitination; negative regulation of neuron apoptosis; response to oxidative stress; negative regulation of transcription, DNA-dependent; regulation of blood vessel size; regulation of mitochondrial depolarization; negative regulation of apoptosis

Disease: Gamma-glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To; Myocardial Infarction, Susceptibility To

NCBI Summary:Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
UniProt Code:P48506
NCBI GenInfo Identifier:1346190
NCBI Gene ID:2729
NCBI Accession:P48506.2
UniProt Secondary Accession:P48506,Q14399,
UniProt Related Accession:P48506
Molecular Weight:72,766 Da
NCBI Full Name:Glutamate--cysteine ligase catalytic subunit
NCBI Synonym Full Names:glutamate-cysteine ligase, catalytic subunit
NCBI Official Symbol:GCLC  
NCBI Official Synonym Symbols:GCL; GCS; GLCL; GLCLC  
NCBI Protein Information:glutamate--cysteine ligase catalytic subunit; gamma-ECS; GCS heavy chain; gamma-glutamylcysteine synthetase
UniProt Protein Name:Glutamate--cysteine ligase catalytic subunit
UniProt Synonym Protein Names:GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase
Protein Family:Glutamate--cysteine ligase
UniProt Gene Name:GCLC  
UniProt Entry Name:GSH1_HUMAN
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