Immunology Antibodies 2

Anti-GBP5 Antibody (CAB17346)

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SKU:
CAB17346
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-GBP5 Antibody
Antibody SKU:CAB17346
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human GBP5
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human GBP5
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:115362
Uniprot:Q96PP8
Cellular Location:Cytoplasm, Golgi apparatus membrane, Lipid-anchor
Calculated MW:55kDa/66kDa
Observed MW:Refer to figures
Synonyms:GBP5, GBP-5
Background:This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:GBP5: Stimulates the NLRP3 inflammasome assembly upon bacterial challenge. Belongs to the GBP family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Hydrolase; Vesicle

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: membrane

Molecular Function:identical protein binding; protein binding

Biological Process: interleukin-1 beta secretion; positive regulation of innate immune response; protein homotetramerization

UniProt Code:Q96PP8
NCBI GenInfo Identifier:37999757
NCBI Gene ID:115362
NCBI Accession:Q96PP8.1
UniProt Secondary Accession:Q96PP8,Q86TM5, B2RCE1,
UniProt Related Accession:Q96PP8
Molecular Weight:55,247 Da
NCBI Full Name:Guanylate-binding protein 5
NCBI Synonym Full Names:guanylate binding protein 5
NCBI Official Symbol:GBP5  
NCBI Official Synonym Symbols:GBP-5  
NCBI Protein Information:guanylate-binding protein 5
UniProt Protein Name:Guanylate-binding protein 5
UniProt Synonym Protein Names:GBP-TA antigen; GTP-binding protein 5; GBP-5; Guanine nucleotide-binding protein 5
Protein Family:Guanylate-binding protein
UniProt Gene Name:GBP5  
UniProt Entry Name:GBP5_HUMAN
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