Immunology Antibodies 2
Anti-GBP1 Antibody (CAB6911)
- SKU:
- CAB6911
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-GBP1 Antibody |
| Antibody SKU: | CAB6911 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_002044.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | 5637(HTB-9) |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_002044.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELAA QLEK KRDD FCKQ NQEA SSDR CSAL LQVI FSPL EEEV KAGI YSKP GGYR LFVQ KLQD LKKK YYEE PRKG IQAE EILQ TYLK SKES MTDA ILQT DQTL TEKE KEIE VERV KAES AQAS AKML QEMQ RKNE QMME QKER SYQE HLKQ LTEK MEND RVQL LKEQ ERTL ALKL QEQE QLLK EGFQ KESR IMKN EIQD LQTK MRRR KACT IS |
| Gene ID: | 2633 |
| Uniprot: | P32455 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor, Secreted |
| Calculated MW: | 67kDa |
| Observed MW: | 68kDa |
| Synonyms: | GBP1 |
| Background: | Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. |
| UniProt Protein Function: | GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3. |
| UniProt Protein Details: | Protein type:Hydrolase; Cell adhesion; Vesicle Chromosomal Location of Human Ortholog: 1p22.2 Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane Molecular Function:actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling |
| NCBI Summary: | Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32455 |
| NCBI GenInfo Identifier: | 311033383 |
| NCBI Gene ID: | 2633 |
| NCBI Accession: | P32455.2 |
| UniProt Secondary Accession: | P32455,Q5T8M1, D3DT26, |
| UniProt Related Accession: | P32455 |
| Molecular Weight: | |
| NCBI Full Name: | Guanylate-binding protein 1 |
| NCBI Synonym Full Names: | guanylate binding protein 1 |
| NCBI Official Symbol: | GBP1 |
| NCBI Protein Information: | guanylate-binding protein 1 |
| UniProt Protein Name: | Guanylate-binding protein 1 |
| UniProt Synonym Protein Names: | GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1 |
| Protein Family: | Guanylate-binding protein |
| UniProt Gene Name: | GBP1 |
| UniProt Entry Name: | GBP1_HUMAN |
 | Western blot analysis of extracts of 5637(HTB-9) cells, using GBP1 antibody (CAB6911) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of U2OS cells using GBP1 antibody (CAB6911). Blue: DAPI for nuclear staining. |
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