Anti-GBP1 Antibody (CAB0570)
- SKU:
- CAB0570
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GBP1
- Synonyms:
- guanylate-binding protein 1
- Research Area:
- Immunology
Description
| Product Name: | GBP1 Rabbit mAb |
| Product Code: | CAB0570 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | GBP1, guanylate-binding protein 1 |
| Applications: | WB, IHC |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GBP1. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, Jurkat, Rat heart |
| Immunogen: | A synthesized peptide derived from human GBP1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2633 |
| Uniprot: | P32455 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor, Secreted |
| Calculated MW: | 68kDa |
| Observed MW: | 68KDa |
| UniProt Protein Function: | GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3. |
| UniProt Protein Details: | Protein type:Hydrolase; Cell adhesion; Vesicle Chromosomal Location of Human Ortholog: 1p22.2 Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane Molecular Function:actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling |
| NCBI Summary: | Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32455 |
| NCBI GenInfo Identifier: | 311033383 |
| NCBI Gene ID: | 2633 |
| NCBI Accession: | P32455.2 |
| UniProt Secondary Accession: | P32455,Q5T8M1, D3DT26, |
| UniProt Related Accession: | P32455 |
| Molecular Weight: | |
| NCBI Full Name: | Guanylate-binding protein 1 |
| NCBI Synonym Full Names: | guanylate binding protein 1 |
| NCBI Official Symbol: | GBP1 |
| NCBI Protein Information: | guanylate-binding protein 1 |
| UniProt Protein Name: | Guanylate-binding protein 1 |
| UniProt Synonym Protein Names: | GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1 |
| Protein Family: | Guanylate-binding protein |
| UniProt Gene Name: | GBP1 |
| UniProt Entry Name: | GBP1_HUMAN |
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Human GBP1 Recombinant Protein (RPES2474)
system_update_altDatasheetHuman GBP1 Recombinant Protein Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IF