Epigenetics & Nuclear Signaling Antibodies 4
Anti-GATAD2B Antibody (CAB9716)
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- SKU:
- CAB9716
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-GATAD2B Antibody |
| Antibody SKU: | CAB9716 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GATAD2B (NP_065750.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, LO2, HeLa, Jurkat, Mouse brain, Mouse kidney, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GATAD2B (NP_065750.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDRM TEDA LRLN LLKR SLDP ADER DDVL AKRL KMEG HEAM ERLK MLAL LKRK DLAN LEVP HELP TKQD GSGV KGYE EKLN GNLR PHGD NRTA GRPG KENI NDEP VDMS ARRS EPER GRLT |
| Gene ID: | 57459 |
| Uniprot: | Q8WXI9 |
| Cellular Location: | Nucleus speckle |
| Calculated MW: | 65kDa |
| Observed MW: | 80kDa |
| Synonyms: | GATAD2B, MRD18, P66beta, p68 |
| Background: | This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with mental retardation. [provided by RefSeq, Jun 2016] |
| UniProt Protein Function: | GATAD2B: a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: nuclear chromatin; nucleoplasm; NuRD complex; protein complex Molecular Function:nucleosomal DNA binding; protein binding Biological Process: ATP-dependent chromatin remodeling; DNA methylation; negative regulation of transcription from RNA polymerase II promoter Disease: Mental Retardation, Autosomal Dominant 18 |
| NCBI Summary: | This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with mental retardation. [provided by RefSeq, Jun 2016] |
| UniProt Code: | Q8WXI9 |
| NCBI GenInfo Identifier: | 50401096 |
| NCBI Gene ID: | 57459 |
| NCBI Accession: | Q8WXI9.1 |
| UniProt Secondary Accession: | Q8WXI9,Q5VUR2, Q7LG68, Q9ULS0, D3DUZ2, |
| UniProt Related Accession: | Q8WXI9 |
| Molecular Weight: | 65,261 Da |
| NCBI Full Name: | Transcriptional repressor p66-beta |
| NCBI Synonym Full Names: | GATA zinc finger domain containing 2B |
| NCBI Official Symbol: | GATAD2B |
| NCBI Official Synonym Symbols: | p68; MRD18; P66beta |
| NCBI Protein Information: | transcriptional repressor p66-beta |
| UniProt Protein Name: | Transcriptional repressor p66-beta |
| UniProt Synonym Protein Names: | GATA zinc finger domain-containing protein 2B; p66/p68 |
| Protein Family: | Transcriptional repressor |
| UniProt Gene Name: | GATAD2B |
| UniProt Entry Name: | P66B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GATAD2B antibody (CAB9716) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded mouse pancreas using GATAD2B Rabbit pAb (CAB9716) at dilution of 1:100 (40x lens). |
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