Signal Transduction Antibodies 2

Anti-GAN Antibody (CAB4205)

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SKU:
CAB4205
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GAN Antibody
Antibody SKU:CAB4205
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GAN (NP_071324.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SW480, Mouse skeletal muscle
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human GAN (NP_071324.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAEG SAVS DPQH AARL LRAL SSFR EESR FCDA HLVL DGEE IPVQ KNIL AAAS PYIR TKLN YNPP KDDG STYK IELE GISV MVMR EILD YIFS GQIR LNED TIQD VVQA ADLL LLTD LKTL CCEF LEGC IAAE NCIG IRDF ALHY CLHH VHYL ATEY LETH FRDV SSTE EFLE LSPQ KLKE VISL EKLN VGNE RYVF EAVI RWIA HDTE IRKV HMKD VMSA LWVS GLDS SYLR EQML NEPL
Gene ID:8139
Uniprot:Q9H2C0
Cellular Location:Cytoplasm, cytoskeleton
Calculated MW:67kDa
Observed MW:71kDa
Synonyms:GAN, GAN1, KLHL16, gigaxonin
Background:This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).
UniProt Protein Function:GAN: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. Defects in GAN are the cause of giant axonal neuropathy (GAN). GAN is a severe autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. It is characterized by neurofilament accumulation, leading to segmental distention of axons.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoskeleton; cytoplasm

Molecular Function:protein binding

Biological Process: protein ubiquitination

Disease: Giant Axonal Neuropathy 1, Autosomal Recessive

NCBI Summary:This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
UniProt Code:Q9H2C0
NCBI GenInfo Identifier:13626745
NCBI Gene ID:8139
NCBI Accession:Q9H2C0.1
UniProt Secondary Accession:Q9H2C0,Q8CA72,
UniProt Related Accession:Q9H2C0
Molecular Weight:597
NCBI Full Name:Gigaxonin
NCBI Synonym Full Names:gigaxonin
NCBI Official Symbol:GAN  
NCBI Official Synonym Symbols:GAN1; KLHL16  
NCBI Protein Information:gigaxonin; kelch-like protein 16; kelch-like family member 16
UniProt Protein Name:Gigaxonin
UniProt Synonym Protein Names:Kelch-like protein 16
Protein Family:Gigaxonin
UniProt Gene Name:GAN  
UniProt Entry Name:GAN_HUMAN
Anti-GAN Antibody (CAB4205)Western blot analysis of extracts of various cell lines, using GAN antibody (CAB4205) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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