Cell Biology Antibodies 12
Anti-Gamma-crystallin C Antibody (CAB9324)
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- SKU:
- CAB9324
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Gamma-crystallin C Antibody |
| Antibody SKU: | CAB9324 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human CRYGC (NP_066269.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human CRYGC (NP_066269.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGKI TFYE DRAF QGRS YETT TDCP NLQP YFSR CNSI RVES GCWM LYER PNYQ GQQY LLRR GEYP DYQQ WMGL SDSI RSCC LIPQ TVSH RLRL YERE DHKG LMME LSED CPSI QDRF HLSE IRSL HVLE GCWV LYEL PNYR GRQY LLRP QEYR RCQD WGAM DAKA GSLR RVVD LY |
| Gene ID: | 1420 |
| Uniprot: | P07315 |
| Cellular Location: | |
| Calculated MW: | 20kDa |
| Observed MW: | 17kDa |
| Synonyms: | CRYGC, CCL, CRYG3, CTRCT2 |
| Background: | This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. |
| UniProt Protein Function: | CRYGC: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. Gamma-crystallins are involved in cataract formation. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 2q33.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; structural constituent of eye lens Biological Process: camera-type eye development; visual perception Disease: Cataract 2, Multiple Types |
| NCBI Summary: | This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P07315 |
| NCBI GenInfo Identifier: | 10518338 |
| NCBI Gene ID: | 1420 |
| NCBI Accession: | NP_066269 |
| UniProt Secondary Accession: | P07315,Q53R50, |
| UniProt Related Accession: | P07315 |
| Molecular Weight: | 23.5kDa (198aa), confirmed by MALDI-TOF |
| NCBI Full Name: | gamma-crystallin C |
| NCBI Synonym Full Names: | crystallin gamma C |
| NCBI Official Symbol: | CRYGC |
| NCBI Official Synonym Symbols: | CCL; CRYG3; CTRCT2 |
| NCBI Protein Information: | gamma-crystallin C |
| UniProt Protein Name: | Gamma-crystallin C |
| UniProt Synonym Protein Names: | Gamma-C-crystallin; Gamma-crystallin 2-1; Gamma-crystallin 3 |
| Protein Family: | Gamma-crystallin |
| UniProt Gene Name: | CRYGC |
| UniProt Entry Name: | CRGC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRYGC antibody (CAB9324) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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