Cell Biology Antibodies 13

Anti-GALR2 Antibody (CAB17577)

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SKU:
CAB17577
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GALR2 Antibody
Antibody SKU:CAB17577
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain, Mouse liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GALR2 (NP_003848.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLRG GQAV STTN LFIL NLGV ADLC FILC CVPF QATI YTLD GWVF GSLL CKAV HFLI FLTM HASS FTLA AVSL DRYL AIRY PLHS RELR TPRN ALAA IGLI W
Gene ID:8811
Uniprot:O43603
Cellular Location:
Calculated MW:
Observed MW:47kDa
Anti-GALR2 Antibody (CAB17577)Western blot - GALR2 Polyclonal Antibody (CAB17577)
Synonyms:GAL2-R, GALNR2, GALR-2, GALR2
Background:Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Protein Function:GALR2: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytosol; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:galanin receptor activity; neuropeptide binding; peptide hormone binding; protein binding

Biological Process: cell surface receptor linked signal transduction; digestion; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inositol phosphate metabolic process; learning and/or memory; multicellular organismal development; muscle contraction; negative regulation of adenylate cyclase activity; neurite development; neuropeptide signaling pathway; phosphatidylinositol metabolic process; positive regulation of transcription from RNA polymerase II promoter; synaptic transmission

NCBI Summary:Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Code:O43603
NCBI GenInfo Identifier:6016094
NCBI Gene ID:8811
NCBI Accession:O43603.1
UniProt Secondary Accession:O43603,Q32MN8, A5JUU4,
UniProt Related Accession:O43603
Molecular Weight:41,700 Da
NCBI Full Name:Galanin receptor type 2
NCBI Synonym Full Names:galanin receptor 2
NCBI Official Symbol:GALR2  
NCBI Official Synonym Symbols:GAL2-R; GALNR2; GALR-2  
NCBI Protein Information:galanin receptor type 2
UniProt Protein Name:Galanin receptor type 2
Protein Family:Galanin receptor
UniProt Gene Name:GALR2  
UniProt Entry Name:GALR2_HUMAN
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