Name: Anti-GALP Antibody (CAB17445)
Brand: Cell Biology Antibodies 7
SKU: CAB17445
Availability: OutOfStock

Antibody Name:	Anti-GALP Antibody
Antibody SKU:	CAB17445
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-116 of human GALP (NP_149097.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	U-87MG

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 25-116 of human GALP (NP_149097.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	APAH RGRG GWTL NSAG YLLG PVLH LPQM GDQD GKRE TALE ILDL WKAI DGLP YSHP PQPS KRNV METF AKPE IGDL GMLS MKIP KEED VLKS
Gene ID:	85569
Uniprot:	Q9UBC7
Cellular Location:
Calculated MW:	13kDa
Observed MW:	20kDa

Synonyms:

GALP

Background:

This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.

UniProt Protein Function:	GALP: Hypothalamic neuropeptide which binds to the G-protein- coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin- releasing hormone secretion. Isoform 2 exhibits potent and dose- dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, a physiologic effects which does not appear to be mediated via GALR1 or GALR2. Belongs to the galanin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: neuropeptide signaling pathway; behavioral response to starvation; defense response to bacterium; regulation of appetite; response to insulin stimulus
NCBI Summary:	This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, may have vasoactive properties and serve as a marker for neuroblastic tumors.[provided by RefSeq, Mar 2009]
UniProt Code:	Q9UBC7
NCBI GenInfo Identifier:	20138432
NCBI Gene ID:	85569
NCBI Accession:	Q9UBC7.1
UniProt Secondary Accession:	Q9UBC7,A1KXL3,
UniProt Related Accession:	Q9UBC7
Molecular Weight:	5,321 Da
NCBI Full Name:	Galanin-like peptide
NCBI Synonym Full Names:	galanin-like peptide
NCBI Official Symbol:	GALP
NCBI Protein Information:	galanin-like peptide; alarin; gal-like peptide
UniProt Protein Name:	Galanin-like peptide
Protein Family:	Galanin-like peptide
UniProt Gene Name:	GALP
UniProt Entry Name:	GALP_HUMAN

Western blot analysis of extracts of U-87MG cells, using GALP antibody (CAB17445) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

ELISA Kits

HumanÂ GALP (Galanin-likeÂ peptideÂ )Â ELISAÂ Kit (HUFI03399)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)