Cell Biology Antibodies 5
Anti-GALNT6 Antibody (CAB14853)
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- SKU:
- CAB14853
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GALNT6 Antibody |
| Antibody SKU: | CAB14853 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-140 of human GALNT6 (NP_009141.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-140 of human GALNT6 (NP_009141.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DVSS REEA TEKP WLKS LVSR KDHV LDLM LEAM NNLR DSMP KLQI RAPE AQQT LFSI NQSC LPGF YTPA ELKP FWER PPQD PNAP GADG KAFQ KSKW TPLE TQEK EEGY KKH |
| Gene ID: | 11226 |
| Uniprot: | Q8NCL4 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 71kDa |
| Observed MW: | 71kDa |
| Synonyms: | GALNT6, GALNAC-T6, GalNAcT6 |
| Background: | This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. |
| UniProt Protein Function: | GALNT6: an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Transferase Chromosomal Location of Human Ortholog: 12q13 Cellular Component: Golgi apparatus; Golgi membrane; perinuclear region of cytoplasm Molecular Function:polypeptide N-acetylgalactosaminyltransferase activity Biological Process: O-glycan processing; protein amino acid O-linked glycosylation |
| NCBI Summary: | This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NCL4 |
| NCBI GenInfo Identifier: | 51316028 |
| NCBI Gene ID: | 11226 |
| NCBI Accession: | Q8NCL4.2 |
| UniProt Secondary Accession: | Q8NCL4,Q8IYH4, Q9H6G2, Q9UIV5, |
| UniProt Related Accession: | Q8NCL4 |
| Molecular Weight: | 71,159 Da |
| NCBI Full Name: | Polypeptide N-acetylgalactosaminyltransferase 6 |
| NCBI Synonym Full Names: | polypeptide N-acetylgalactosaminyltransferase 6 |
| NCBI Official Symbol: | GALNT6 |
| NCBI Official Synonym Symbols: | GalNAcT6; GALNAC-T6 |
| NCBI Protein Information: | polypeptide N-acetylgalactosaminyltransferase 6 |
| UniProt Protein Name: | Polypeptide N-acetylgalactosaminyltransferase 6 |
| UniProt Synonym Protein Names: | Polypeptide GalNAc transferase 6; GalNAc-T6; pp-GaNTase 6; Protein-UDP acetylgalactosaminyltransferase 6; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6 |
| Protein Family: | Polypeptide N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | GALNT6 |
| UniProt Entry Name: | GALT6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GALNT6 antibody (CAB14853) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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