Cell Biology Antibodies 5

Anti-GALNT10 Antibody (CAB14909)

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SKU:
CAB14909
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GALNT10 Antibody
Antibody SKU:CAB14909
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 444-603 of human GALNT10 (NP_938080.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SGC-7901, OVCAR3, Mouse brain, Mouse testis, Rat heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 444-603 of human GALNT10 (NP_938080.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WDLP KFYP PVEP PAAA WGEI RNVG TGLC ADTK HGAL GSPL RLEG CVRG RGEA AWNN MQVF TFTW REDI RPGD PQHT KKFC FDAI SHTS PVTL YDCH SMKG NQLW KYRK DKTL YHPV SGSC MDCS ESDH RIFM NTCN PSSL TQQW LFEH TNST VLEK FNRN
Gene ID:55568
Uniprot:Q86SR1
Cellular Location:Golgi apparatus membrane, Single-pass type II membrane protein
Calculated MW:31kDa/41kDa/61kDa/68kDa
Observed MW:69kDa
Synonyms:GALNT10, GALNACT10, PPGALNACT10, PPGANTASE10
Background:This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.
UniProt Protein Function:GALNT10: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transferase; Glycan Metabolism - O-glycan biosynthesis; EC 2.4.1.41

Chromosomal Location of Human Ortholog: 5q33.2

Cellular Component: Golgi membrane; integral to membrane

Molecular Function:metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity; carbohydrate binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; post-translational protein modification

NCBI Summary:This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
UniProt Code:Q86SR1
NCBI GenInfo Identifier:38195091
NCBI Gene ID:55568
NCBI Accession:NP_938080
UniProt Secondary Accession:Q86SR1,Q6IN56, Q86VP8, Q8IXJ2, Q8TEJ2, Q96IV2, Q9H8E1 Q9Y4M4, B3KXC9,
UniProt Related Accession:Q86SR1
Molecular Weight:31,833 Da
NCBI Full Name:polypeptide N-acetylgalactosaminyltransferase 10
NCBI Synonym Full Names:polypeptide N-acetylgalactosaminyltransferase 10
NCBI Official Symbol:GALNT10  
NCBI Official Synonym Symbols:GALNACT10; PPGALNACT10; PPGANTASE10  
NCBI Protein Information:polypeptide N-acetylgalactosaminyltransferase 10; GalNAc transferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
UniProt Protein Name:Polypeptide N-acetylgalactosaminyltransferase 10
UniProt Synonym Protein Names:Polypeptide GalNAc transferase 10; GalNAc-T10; pp-GaNTase 10; Protein-UDP acetylgalactosaminyltransferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
Protein Family:Polypeptide N-acetylgalactosaminyltransferase
UniProt Gene Name:GALNT10  
UniProt Entry Name:GLT10_HUMAN
Anti-GALNT10 Antibody (CAB14909)Western blot analysis of extracts of various cell lines, using GALNT10 antibody (CAB14909) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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