Metabolism Antibodies 1

Anti-GALK1 Antibody (CAB15274)

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SKU:
CAB15274
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-GALK1 Antibody
Antibody SKU:CAB15274
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GALK1 (NP_000145.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-251MG, HepG2, HeLa, MCF7, Mouse heart, Mouse brain, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GALK1 (NP_000145.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAL RQPQ VAEL LAEA RRAF REEF GAEP ELAV SAPG RVNL IGEH TDYN QGLV LPMA LELM TVLV GSPR KDGL VSLL TTSE GADE PQRL QFPL PTAQ RSLE PGTP RWAN YVKG VIQY YPAA
Gene ID:2584
Uniprot:P51570
Cellular Location:
Calculated MW:42kDa/45kDa
Observed MW:42kDa
Synonyms:GALK1, GALK, GK1, HEL-S-19
Background:Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population.
UniProt Protein Function:GALK1: Major enzyme for galactose metabolism. Defects in GALK1 are the cause of galactosemia II (GALCT2). Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses. Belongs to the GHMP kinase family. GalK subfamily.
UniProt Protein Details:

Protein type:Kinase, other; Carbohydrate Metabolism - galactose; EC 2.7.1.6; Carbohydrate Metabolism - amino sugar and nucleotide sugar

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: cytoplasm; cytosol; membrane

Molecular Function:ATP binding; galactokinase activity; galactose binding

Biological Process: galactose catabolic process; galactose metabolic process

Disease: Galactokinase Deficiency

NCBI Summary:Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]
UniProt Code:P51570
NCBI GenInfo Identifier:1730187
NCBI Gene ID:2584
NCBI Accession:P51570.1
UniProt Secondary Accession:P51570,B2RC07, B4E1G6,
UniProt Related Accession:P51570
Molecular Weight:45,358 Da
NCBI Full Name:Galactokinase
NCBI Synonym Full Names:galactokinase 1
NCBI Official Symbol:GALK1  
NCBI Official Synonym Symbols:GK1; GALK; HEL-S-19  
NCBI Protein Information:galactokinase
UniProt Protein Name:Galactokinase
UniProt Synonym Protein Names:Galactose kinase
UniProt Gene Name:GALK1  
UniProt Entry Name:GALK1_HUMAN
Anti-GALK1 Antibody (CAB15274)Western blot analysis of extracts of various cell lines, using GALK1 antibody (CAB15274) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60S.
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system_update_altDatasheetHuman GALK1/Galactokinase Recombinant Protein Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabo