Antibody Name:	Anti-GAL Antibody
Antibody SKU:	CAB1991
Antibody Size:	20uL, 50uL, 100uL
Application:	IHC
Reactivity:	Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-123 of human GAL (NP_057057.2).

Application:	IHC
Recommended Dilution:	IHC 1:50 - 1:200
Reactivity:	Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-123 of human GAL (NP_057057.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ASAG LWSP AKEK RGWT LNSA GYLL GPHA VGNH RSFS DKNG LTSK RELR PEDD MKPG SFDR SIPE NNIM RTII EFLS FLHL KEAG ALDR LLDL PAAA SSED IERS
Gene ID:	51083
Uniprot:	P22466
Cellular Location:	Secreted
Calculated MW:	13kDa
Observed MW:	Refer to figures

Synonyms:

GAL, ETL8, GAL-GMAP, GALN, GLNN, GMAP

Background:

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system.

UniProt Protein Function:	Galanin: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. Belongs to the galanin family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: Golgi apparatus; extracellular space; cell soma; extracellular region; secretory granule Molecular Function:type 3 galanin receptor binding; neuropeptide hormone activity; protein binding; type 2 galanin receptor binding; type 1 galanin receptor binding Biological Process: response to drug; nervous system development; positive regulation of cortisol secretion; positive regulation of apoptosis; positive regulation of catagen; negative regulation of lymphocyte proliferation; response to insulin stimulus; cAMP-mediated signaling; response to estrogen stimulus; neuropeptide signaling pathway; insulin secretion; regulation of glucocorticoid metabolic process; feeding behavior; positive regulation of transcription from RNA polymerase II promoter; inflammatory response Disease: Epilepsy, Familial Temporal Lobe, 8
NCBI Summary:	Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009]
UniProt Code:	P22466
NCBI GenInfo Identifier:	2506449
NCBI Gene ID:	51083
NCBI Accession:	P22466.3
UniProt Secondary Accession:	P22466,Q14413,
UniProt Related Accession:	P22466
Molecular Weight:	13,302 Da
NCBI Full Name:	Galanin peptides
NCBI Synonym Full Names:	galanin/GMAP prepropeptide
NCBI Official Symbol:	GAL
NCBI Official Synonym Symbols:	GALN; GLNN; GMAP; GAL-GMAP
NCBI Protein Information:	galanin peptides; galanin prepropeptide; galanin-message-associated peptide; galanin-related peptide
UniProt Protein Name:	Galanin peptides
Protein Family:	Galanin
UniProt Gene Name:	GAL
UniProt Entry Name:	GALA_HUMAN