Cell Death Antibodies 1
Anti-GADD45G Antibody (CAB10286)
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- SKU:
- CAB10286
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-GADD45G Antibody |
| Antibody SKU: | CAB10286 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human GADD45G (NP_006696.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | RAW264.7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of human GADD45G (NP_006696.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTLE EVRG QDTV PEST ARMQ GAGK ALHE LLLS AQRQ GCLT AGVY ESAK VLNV DPDN VTFC VLAA GEED EGDI ALQI HFTL IQAF CCEN DIDI VRVG DVQR LAAI VGAG EEAG APGD LHCI LISN PNED AWKD PALE KLSL FCEE SRSV NDWV PSIT LPE |
| Gene ID: | 10912 |
| Uniprot: | O95257 |
| Cellular Location: | |
| Calculated MW: | 17kDa |
| Observed MW: | 17kDa |
| Synonyms: | GADD45G, CR6, DDIT2, GADD45gamma, GRP17 |
| Background: | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. |
| UniProt Protein Function: | GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family. |
| UniProt Protein Details: | Protein type:Apoptosis; DNA repair, damage; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 9q22.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding Biological Process: activation of MAPKKK activity; positive regulation of apoptosis; positive regulation of JNK cascade; regulation of cell cycle |
| NCBI Summary: | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95257 |
| NCBI GenInfo Identifier: | 6919892 |
| NCBI Gene ID: | 10912 |
| NCBI Accession: | O95257.1 |
| UniProt Secondary Accession: | O95257,Q5VZ87, Q9C076, |
| UniProt Related Accession: | O95257 |
| Molecular Weight: | 17kDa |
| NCBI Full Name: | Growth arrest and DNA damage-inducible protein GADD45 gamma |
| NCBI Synonym Full Names: | growth arrest and DNA damage inducible gamma |
| NCBI Official Symbol: | GADD45G |
| NCBI Official Synonym Symbols: | CR6; DDIT2; GRP17; GADD45gamma |
| NCBI Protein Information: | growth arrest and DNA damage-inducible protein GADD45 gamma |
| UniProt Protein Name: | Growth arrest and DNA damage-inducible protein GADD45 gamma |
| UniProt Synonym Protein Names: | Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2 |
| Protein Family: | Growth arrest and DNA damage-inducible protein |
| UniProt Gene Name: | GADD45G |
 | Western blot analysis of extracts of RAW264.7 cells, using GADD45G antibody (CAB10286) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min. |
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