Signal Transduction Antibodies 3
Anti-GABRR1 Antibody (CAB5745)
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- SKU:
- CAB5745
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GABRR1 Antibody |
| Antibody SKU: | CAB5745 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 365-465 of human GABRR1 (NP_002033.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A673, Mouse eye, Mouse heart, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 365-465 of human GABRR1 (NP_002033.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VNYL TTVQ ERKE QKLR EKLP CTSG LPPP RTAM LDGN YSDG EVND LDNY MPEN GEKP DRMM VQLT LASE RSSP QRKS QRSS YVSM RIDT HAID KYSR IIFP A |
| Gene ID: | 2569 |
| Uniprot: | P24046 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 45kDa/53kDa/55kDa |
| Observed MW: | 56kDa |
| Synonyms: | GABRR1 |
| Background: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GABRR1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Transporter; Transporter, ion channel; Channel, ligand-gated; Membrane protein, multi-pass; Channel, chloride; Membrane protein, integral Chromosomal Location of Human Ortholog: 6q15 Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function:chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity Biological Process: synaptic transmission; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway |
| NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | P24046 |
| NCBI GenInfo Identifier: | 223590210 |
| NCBI Gene ID: | 2569 |
| NCBI Accession: | P24046.2 |
| UniProt Related Accession: | P24046 |
| Molecular Weight: | |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit rho-1 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor rho1 subunit |
| NCBI Official Symbol: | GABRR1 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit rho-1 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit rho-1 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit rho-1; GABA(C) receptor |
| UniProt Gene Name: | GABRR1 |
| UniProt Entry Name: | GBRR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GABRR1 antibody (CAB5745) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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