Signal Transduction Antibodies 2

Anti-GABRR1 Antibody (CAB2937)

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SKU:
CAB2937
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRR1 Antibody
Antibody SKU:CAB2937
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human GABRR1 (NP_002033.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human GABRR1 (NP_002033.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MLAV PNMR FGIF LLWW GWVL ATES RMHW PGRE VHEM SKKG RPQR QRRE VHED AHKQ VSPI LRRS PDIT KSPL TKSE QLLR
Gene ID:2569
Uniprot:P24046
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:45kDa/53kDa/55kDa
Observed MW:56kDa
Synonyms:GABRR1
Background:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GABRR1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, misc.; Transporter; Transporter, ion channel; Channel, ligand-gated; Membrane protein, multi-pass; Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function:chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway

NCBI Summary:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:P24046
NCBI GenInfo Identifier:223590210
NCBI Gene ID:2569
NCBI Accession:P24046.2
UniProt Related Accession:P24046
Molecular Weight:
NCBI Full Name:Gamma-aminobutyric acid receptor subunit rho-1
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor rho1 subunit
NCBI Official Symbol:GABRR1  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit rho-1
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit rho-1
UniProt Synonym Protein Names:GABA(A) receptor subunit rho-1; GABA(C) receptor
UniProt Gene Name:GABRR1  
UniProt Entry Name:GBRR1_HUMAN
Anti-GABRR1 Antibody (CAB2937)Western blot analysis of extracts of various cell lines, using GABRR1 antibody (CAB2937) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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