Signal Transduction Antibodies 1

Anti-GABRG1 Antibody (CAB14240)

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SKU:
CAB14240
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRG1 Antibody
Antibody SKU:CAB14240
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-260 of human GABRG1 (NP_775807.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-260 of human GABRG1 (NP_775807.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HSCP LEFS SYGY PKNE IEYK WKKP SVEV ADPK YWRL YQFA FVGL RNST EITH TISG DYVI M
Gene ID:2565
Uniprot:Q8N1C3
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:53kDa
Observed MW:54kDa
Synonyms:GABRG1
Background:The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4.
UniProt Protein Function:GABRG1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p12

Molecular Function:GABA-A receptor activity

NCBI Summary:The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N1C3
NCBI GenInfo Identifier:209572630
NCBI Gene ID:2565
NCBI Accession:Q8N1C3.2
UniProt Secondary Accession:Q8N1C3,Q5H9T8,
UniProt Related Accession:Q8N1C3
Molecular Weight:53,595 Da
NCBI Full Name:Gamma-aminobutyric acid receptor subunit gamma-1
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor gamma1 subunit
NCBI Official Symbol:GABRG1  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit gamma-1
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit gamma-1
UniProt Synonym Protein Names:GABA(A) receptor subunit gamma-1
Protein Family:Gamma-aminobutyric acid receptor
UniProt Gene Name:GABRG1  
UniProt Entry Name:GBRG1_HUMAN
Anti-GABRG1 Antibody (CAB14240)Western blot analysis of extracts of various cell lines, using GABRG1 antibody (CAB14240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-GABRG1 Antibody (CAB14240)Immunofluorescence analysis of C6 cells using GABRG1 Rabbit pAb (CAB14240) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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