Signal Transduction Antibodies 2

Anti-GABRB2 Antibody (CAB1876)

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SKU:
CAB1876
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRB2 Antibody
Antibody SKU:CAB1876
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-244 of human GABRB2 (NP_000804.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-244 of human GABRB2 (NP_000804.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SVND PSNM SLVK ETVD RLLK GYDI RLRP DFGG PPVA VGMN IDIA SIDM VSEV NMDY TLTM YFQQ AWRD KRLS YNVI PLNL TLDN RVAD QLWV PDTY FLND KKSF VHGV TVKN RMIR LHPD GTVL YGLR ITTT AACM MDLR RYPL DEQN CTLE IESY GYTT DDIE FYWR GDDN AVTG VTKI ELPQ FSIV DYKL ITKK VVFS TGSY PRLS LSFK LKRN IGY
Gene ID:2561
Uniprot:P47870
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:36kDa/42kDa/54kDa/59kDa
Observed MW:55KDa
Synonyms:GABRB2
Background:The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
UniProt Protein Function:Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
NCBI Summary:The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
UniProt Code:P47870
NCBI GenInfo Identifier:292495010
NCBI Gene ID:2561
NCBI Accession:P47870.2
UniProt Related Accession:P47870
Molecular Weight:~ 59kDa
NCBI Full Name:Gamma-aminobutyric acid receptor subunit beta-2
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor subunit beta2
NCBI Official Symbol:GABRB2  
NCBI Official Synonym Symbols:ICEE2  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit beta-2
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit beta-2
UniProt Synonym Protein Names:GABA(A) receptor subunit beta-2
UniProt Gene Name:GABRB2  
UniProt Entry Name:GBRB2_HUMAN
Anti-GABRB2 Antibody (CAB1876)Western blot analysis of extracts of various cell lines, using GABRB2 Rabbit pAb (CAB1876) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
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