Signal Transduction Antibodies 1

Anti-GABRA6 Antibody (CAB12750)

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SKU:
CAB12750
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRA6 Antibody
Antibody SKU:CAB12750
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 344-453 of human GABRA6 (NP_000802.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, HT-1080, Mouse brain, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 344-453 of human GABRA6 (NP_000802.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PPTV TISK ATEP LEAE IVLH PDSK YHLK KRIT SLSL PIVS SSEA NKVL TRAP ILQS TPVT PPPL SPAF GGTS KIDQ YSRI LFPV AFAG FNLV YWVV YLSK DTME VSSS VE
Gene ID:2559
Uniprot:Q16445
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:51kDa
Observed MW:51kDa
Synonyms:GABRA6
Background:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
UniProt Protein Function:GABRA6: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.
UniProt Protein Details:

Protein type:Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:benzodiazepine receptor activity; GABA-A receptor activity

Biological Process: signal transduction; transport

NCBI Summary:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q16445
NCBI GenInfo Identifier:126302548
NCBI Gene ID:2559
NCBI Accession:Q16445.2
UniProt Secondary Accession:Q16445,Q4VAV2, A8K096,
UniProt Related Accession:Q16445
Molecular Weight:51kDa
NCBI Full Name:Gamma-aminobutyric acid receptor subunit alpha-6
NCBI Synonym Full Names:gamma-aminobutyric acid type A receptor alpha6 subunit
NCBI Official Symbol:GABRA6  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit alpha-6
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit alpha-6
UniProt Synonym Protein Names:GABA(A) receptor subunit alpha-6
Protein Family:Gamma-aminobutyric acid receptor
UniProt Gene Name:GABRA6  
Anti-GABRA6 Antibody (CAB12750)Western blot analysis of extracts of various cell lines, using GABRA6 antibody (CAB12750) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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