Signal Transduction Antibodies 1
Anti-GABRA5 Antibody (CAB13984)
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- SKU:
- CAB13984
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-GABRA5 Antibody |
| Antibody SKU: | CAB13984 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-259 of human GABRA5 (NP_000801.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-259 of human GABRA5 (NP_000801.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QMPT SSVK DETN DNIT IFTR ILDG LLDG YDNR LRPG LGER ITQV RTDI YVTS FGPV SDTE MEYT IDVF FRQS WKDE RLRF KGPM QRLP LNNL LASK IWTP DTFF HNGK KSIA HNMT TPNK LLRL EDDG TLLY TMRL TISA ECPM QLED FPMD AHAC PLKF GSYA YPNS EVVY VWTN GSTK SVVV AEDG SRLN QYHL MGQT VGTE NIST STGE YTIM TAHF HLKR KIGY |
| Gene ID: | 2558 |
| Uniprot: | P31644 |
| Cellular Location: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| Calculated MW: | 52kDa |
| Observed MW: | 60kDa |
| Synonyms: | GABRA5 |
| Background: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. |
| UniProt Protein Function: | GABRA5: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q12 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:GABA-A receptor activity; receptor activity; transporter activity Biological Process: positive regulation of defense response to virus by host; signal transduction; transport |
| NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31644 |
| NCBI GenInfo Identifier: | 15030265 |
| NCBI Gene ID: | 2558 |
| NCBI Accession: | BC011403 |
| UniProt Secondary Accession: | P31644,Q14DC2, Q53XL6, Q9NYT3, Q9NYT4, Q9NYT5, A8K338 |
| UniProt Related Accession: | P31644,AAB22608 |
| Molecular Weight: | 52,146 Da |
| NCBI Full Name: | Homo sapiens cDNA clone IMAGE:3868411, **** WARNING: chimeric clone **** |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha5 subunit |
| NCBI Official Symbol: | GABRA5 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-5 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-5 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA5 |
| UniProt Entry Name: | GBRA5_HUMAN |
 | Western blot analysis of extracts of rat skeletal muscle, using GABRA5 antibody (CAB13984) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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