Signal Transduction Antibodies 2

Anti-GABRA2 Antibody (CAB1803)

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SKU:
CAB1803
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-GABRA2 Antibody
Antibody SKU:CAB1803
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:22Rv1, Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ARNS LPKV AYAT AMDW FIAV CYAF VFSA LIEF ATVN YFTK RGWA WDGK SVVN DKKK EKAS VMIQ NNAY AVAV ANYA PNLS KDPV LSTI SKSA TTPE PNKK P
Gene ID:2555
Uniprot:P47869
Cellular Location:Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:51kDa/52kDa
Observed MW:50kDa
Synonyms:GABRA2
Background:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GABRA2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
UniProt Protein Details:

Protein type:Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: postsynaptic membrane; axon; plasma membrane; cell junction; integral to synaptic vesicle membrane

Molecular Function:chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; neurotransmitter transport; regulation of neurotransmitter levels; transmembrane transport; gamma-aminobutyric acid signaling pathway

Disease: Alcohol Dependence

NCBI Summary:GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Code:P47869
NCBI GenInfo Identifier:126302547
NCBI Gene ID:2555
NCBI Accession:P47869.2
UniProt Secondary Accession:P47869,Q59G14, A8K0U7, B7Z1H8,
UniProt Related Accession:P47869
Molecular Weight:451
NCBI Full Name:Gamma-aminobutyric acid receptor subunit alpha-2
NCBI Synonym Full Names:gamma-aminobutyric acid (GABA) A receptor, alpha 2
NCBI Official Symbol:GABRA2  
NCBI Protein Information:gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor, alpha 2; GABA(A) receptor subunit alpha-2
UniProt Protein Name:Gamma-aminobutyric acid receptor subunit alpha-2
UniProt Synonym Protein Names:GABA(A) receptor subunit alpha-2
Protein Family:Gamma-aminobutyric acid receptor
UniProt Gene Name:GABRA2  
UniProt Entry Name:GBRA2_HUMAN
Anti-GABRA2 Antibody (CAB1803)Western blot analysis of extracts of various cell lines, using GABRA2 antibody (CAB1803) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3s.
Anti-GABRA2 Antibody (CAB1803)Immunohistochemistry of paraffin-embedded mouse stomach using GABRA2 Rabbit pAb (CAB1803) at dilution of 1:250 (40x lens).
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