Cell Biology Antibodies 2

Anti-GABBR1 Antibody (CAB10504)

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SKU:
CAB10504
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GABBR1 Antibody
Antibody SKU:CAB10504
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human GABBR1 (NP_068703.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:DU145, HT-1080, HT-29, HeLa, Mouse brain, Mouse spinal cord, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human GABBR1 (NP_068703.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EVFT STLD DLEE RVKE AGIE ITFR QSFF SDPA VPVK NLKR QDAR IIVG LFYE TEAR KVFC EVYK ERLF GKKY VWFL IGWY ADNW FKIY DPSI NCTV DEMT EAVE GHIT TEIV MLNP ANTR SISN MTSQ EFVE KLTK RLKR HPEE TGGF QEAP LAYD AIWA LALA LNKT SGGG GRSG VRLE DFNY NNQT ITDQ IYRA MNSS SFEG VSGH VVFD ASGS RMAW TLIE QLQG GSYK KIGY YDST KDDL SWSK TDKW IGGS PPAD Q
Gene ID:2550
Uniprot:Q9UBS5
Cellular Location:Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, Secreted, dendrite, postsynaptic cell membrane, synapse
Calculated MW:65kDa/95kDa/101kDa/104kDa/108kDa
Observed MW:95kDa
Synonyms:GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A
Background:This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.
UniProt Protein Function:Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.
NCBI Summary:This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]
UniProt Code:Q9UBS5
NCBI GenInfo Identifier:12643873
NCBI Gene ID:2550
NCBI Accession:Q9UBS5.1
UniProt Secondary Accession:Q9UBS5,O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8 Q5SUL3, Q71SG6, Q86W60, Q9UQQ0, B0UXY7,
UniProt Related Accession:Q9UBS5
Molecular Weight:65,082 Da
NCBI Full Name:Gamma-aminobutyric acid type B receptor subunit 1
NCBI Synonym Full Names:gamma-aminobutyric acid type B receptor subunit 1
NCBI Official Symbol:GABBR1  
NCBI Official Synonym Symbols:GB1; GPRC3A; GABABR1; GABBR1-3  
NCBI Protein Information:gamma-aminobutyric acid type B receptor subunit 1
UniProt Protein Name:Gamma-aminobutyric acid type B receptor subunit 1
Protein Family:Gamma-aminobutyric acid type B receptor
UniProt Gene Name:GABBR1  
UniProt Entry Name:GABR1_HUMAN
Anti-GABBR1 Antibody (CAB10504)Western blot analysis of extracts of various cell lines, using GABBR1 antibody (CAB10504) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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