Name: Anti-GABARAPL2 Antibody (CAB9585)
Brand: Autophagy Antibodies
SKU: CAB9585
Availability: OutOfStock

Antibody Name:	Anti-GABARAPL2 Antibody
Antibody SKU:	CAB9585
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human GABARAPL2

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	PC-3, RD, Mouse brain, Rat brain

Immunogen:	A synthesized peptide derived from human GABARAPL2
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	11345
Uniprot:	P60520
Cellular Location:
Calculated MW:	14kDa
Observed MW:	16KDa

Synonyms:	ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2
Background:

UniProt Protein Function:	GABARAPL2: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Implicated in intra-Golgi transport and post-mitotic Golgi re-assembly. Modulates the activity of SNAREs in the Golgi apparatus and is therefore an essential component of intra-Golgi transport and post-mitotic Golgi re-assembly. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin. Interacts with ULK1. Phosphorylated upon DNA damage, probably by ATM or ATR.
UniProt Protein Details:	Protein type:Vesicle; Microtubule-binding; Ubiquitin-like modifier; Autophagy; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: autophagic vacuole; cytoplasm; cytosol; Golgi apparatus; Golgi membrane; intracellular Molecular Function:ATPase binding; beta-tubulin binding; GABA receptor binding; protein binding; SNARE binding; ubiquitin protein ligase binding Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; intra-Golgi vesicle-mediated transport; macroautophagy; mitochondrion degradation; positive regulation of ATPase activity
UniProt Code:	P60520
NCBI GenInfo Identifier:	44888808
NCBI Gene ID:	11345
NCBI Accession:	P60520.1
UniProt Secondary Accession:	P60520,O08765, Q6FG91, Q9DCP8, Q9UQF7,
UniProt Related Accession:	P60520
Molecular Weight:	13,667 Da
NCBI Full Name:	Gamma-aminobutyric acid receptor-associated protein-like 2
NCBI Synonym Full Names:	GABA type A receptor associated protein like 2
NCBI Official Symbol:	GABARAPL2
NCBI Official Synonym Symbols:	ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16
NCBI Protein Information:	gamma-aminobutyric acid receptor-associated protein-like 2
UniProt Protein Name:	Gamma-aminobutyric acid receptor-associated protein-like 2
UniProt Synonym Protein Names:	GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; GEF-2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; GATE-16; MAP1 light chain 3-related protein
Protein Family:	Gamma-aminobutyric acid receptor-associated protein
UniProt Gene Name:	GABARAPL2
UniProt Entry Name:	GBRL2_HUMAN