Cell Death Antibodies 2
Anti-GABARAP Antibody (CAB4335)
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- SKU:
- CAB4335
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-GABARAP Antibody |
| Antibody SKU: | CAB4335 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GABARAP |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, 293T+Chloroquine, NIH/3T3, NIH/3T3+Chloroquine, C6, C6+Chloroquine |
| Immunogen: | A synthesized peptide derived from human GABARAP |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11337 |
| Uniprot: | O95166 |
| Cellular Location: | |
| Calculated MW: | 17kDa |
| Observed MW: | 16KDa |
| Synonyms: | ATG8A, GABARAP-a, MM46 |
| Background: | Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GABARAP: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1. |
| UniProt Protein Details: | Protein type:Autophagy; Adaptor/scaffold; Microtubule-binding; Ubiquitin-like modifier; Vesicle Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: microtubule; smooth endoplasmic reticulum; lysosome; autophagic vacuole; cytosol; actin cytoskeleton; Golgi membrane; microtubule associated complex; extrinsic to membrane; perinuclear region of cytoplasm; plasma membrane; axoneme; cytoplasmic vesicle Molecular Function:protein binding; microtubule binding; GABA receptor binding; beta-tubulin binding Biological Process: synaptic transmission; induction of apoptosis via death domain receptors; mitochondrion degradation; microtubule cytoskeleton organization and biogenesis; autophagic vacuole formation; protein targeting |
| NCBI Summary: | Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95166 |
| NCBI GenInfo Identifier: | 44887916 |
| NCBI Gene ID: | 11337 |
| NCBI Accession: | O95166.1 |
| UniProt Related Accession: | O95166 |
| Molecular Weight: | 117 |
| NCBI Full Name: | Gamma-aminobutyric acid receptor-associated protein |
| NCBI Synonym Full Names: | GABA(A) receptor-associated protein |
| NCBI Official Symbol: | GABARAP |
| NCBI Official Synonym Symbols: | MM46; ATG8A; GABARAP-a |
| NCBI Protein Information: | gamma-aminobutyric acid receptor-associated protein |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor-associated protein |
| UniProt Synonym Protein Names: | GABA(A) receptor-associated protein; MM46 |
| Protein Family: | Gamma-aminobutyric acid receptor-associated protein |
| UniProt Gene Name: | GABARAP |
| UniProt Entry Name: | GBRAP_HUMAN |
 | Western blot - GABARAP Rabbit mAb (CAB4335) |
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