Cell Biology Antibodies 3

Anti-GAB2 Antibody (CAB13066)

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SKU:
CAB13066
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-GAB2 Antibody
Antibody SKU:CAB13066
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_536739.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_536739.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ENSR SVAA TIPR RNTL PAMD NSRL HRAS SCET YEYP QRGG ESAG RSAE SMSD GVGS FLPG KMIV GRSD STNS EDNY VPMN PGSS TLLA MERA GDNS QSVY IPMS PGAH HFDS LGYP STTL PVHR GPSR GSEI QPPP VNRN LKPD RKAK PTPL DLRN NTVI DELP FKSP ITKS WSRA NHTF NSSS SQYC RPIS TQSI TSTD SGDS EENY VPMQ NPVS ASPV PSGT NSPA PKKS TGSV DYLA LDFQ PSSP SPHR KPST SSVT SDEK VDYV QVDK EKTQ ALQN TMQE WTDV RQSS EPSK GAKL
Gene ID:9846
Uniprot:Q9UQC2
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:69kDa/74kDa
Observed MW:74kDa
Synonyms:GAB2
Background:This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
UniProt Protein Function:GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation

NCBI Summary:This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Code:Q9UQC2
NCBI GenInfo Identifier:46396035
NCBI Gene ID:9846
NCBI Accession:Q9UQC2.1
UniProt Secondary Accession:Q9UQC2,O60317, A2RRM2, A6NEW9, A7MD36,
UniProt Related Accession:Q9UQC2
Molecular Weight:69,968 Da
NCBI Full Name:GRB2-associated-binding protein 2
NCBI Synonym Full Names:GRB2 associated binding protein 2
NCBI Official Symbol:GAB2  
NCBI Protein Information:GRB2-associated-binding protein 2
UniProt Protein Name:GRB2-associated-binding protein 2
UniProt Synonym Protein Names:GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
Protein Family:GRB2-associated-binding protein
UniProt Gene Name:GAB2  
UniProt Entry Name:GAB2_HUMAN
Anti-GAB2 Antibody (CAB13066)Western blot analysis of extracts of various cell lines, using GAB2 antibody (CAB13066) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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