Cell Biology Antibodies 5
Anti-GAB1 Antibody (CAB14534)
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- SKU:
- CAB14534
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-GAB1 Antibody |
| Antibody SKU: | CAB14534 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GAB1 (NP_997006.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human GAB1 (NP_997006.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSGG EVVC SGWL RKSP PEKK LKRY AWKR RWFV LRSG RLTG DPDV LEYY KNDH AKKP IRII DLNL CQQV DAGL TFNK KEFE NSYI FDIN TIDR IFYL VADS EEEM NKWV RCIC DICG FNPT EEDP VKPP GSSL QAPA DLPL AINT APPS TQ |
| Gene ID: | 2549 |
| Uniprot: | Q13480 |
| Cellular Location: | |
| Calculated MW: | 76kDa/80kDa |
| Observed MW: | 110kDa |
| Synonyms: | GAB1, GRB2 |
| Background: | The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q31.21 Cellular Component: cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity; signal transducer activity Biological Process: activation of JNK activity; cell proliferation; epidermal growth factor receptor signaling pathway; epidermis development; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; regulation of cell migration; response to oxidative stress |
| NCBI Summary: | The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q13480 |
| NCBI GenInfo Identifier: | 90180201 |
| NCBI Gene ID: | 2549 |
| NCBI Accession: | Q13480.2 |
| UniProt Secondary Accession: | Q13480,Q4W5G2, Q6P1W2, A8K152, |
| UniProt Related Accession: | Q13480 |
| Molecular Weight: | 80,005 Da |
| NCBI Full Name: | GRB2-associated-binding protein 1 |
| NCBI Synonym Full Names: | GRB2 associated binding protein 1 |
| NCBI Official Symbol: | GAB1 |
| NCBI Protein Information: | GRB2-associated-binding protein 1 |
| UniProt Protein Name: | GRB2-associated-binding protein 1 |
| UniProt Synonym Protein Names: | GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 |
| Protein Family: | GPI transamidase component |
| UniProt Gene Name: | GAB1 |
| UniProt Entry Name: | GAB1_HUMAN |
 | Western blot analysis of extracts of Mouse testis, using GAB1 antibody (CAB14534) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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