Cell Biology Antibodies 18
Anti-FZD8 Antibody (CAB18393)
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- SKU:
- CAB18393
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FZD8 Antibody |
| Antibody SKU: | CAB18393 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human FZD8. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-549, HeLa, Mouse liver, Rat liver |
| Immunogen: | Recombinant protein of human FZD8. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8325 |
| Uniprot: | Q9H461 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 73kDa |
 | Western blot - FZD8 Rabbit pAb (CAB18393) |
| Synonyms: | FZ-8, hFZ8, FZD8 |
| Background: |
| UniProt Protein Function: | FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, Fz/Smo family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: Golgi apparatus; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; receptor binding; PDZ domain binding Biological Process: neuron differentiation; positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin |
| NCBI Summary: | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H461 |
| NCBI GenInfo Identifier: | 17433053 |
| NCBI Gene ID: | 8325 |
| NCBI Accession: | Q9H461.1 |
| UniProt Related Accession: | Q9H461 |
| Molecular Weight: | 73,300 Da |
| NCBI Full Name: | Frizzled-8 |
| NCBI Synonym Full Names: | frizzled class receptor 8 |
| NCBI Official Symbol: | FZD8 |
| NCBI Official Synonym Symbols: | FZ-8; hFZ8 |
| NCBI Protein Information: | frizzled-8; frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8 |
| UniProt Protein Name: | Frizzled-8 |
| Protein Family: | Frizzled |
| UniProt Gene Name: | FZD8 |
| UniProt Entry Name: | FZD8_HUMAN |
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