Name: Anti-FZD8 Antibody (CAB18393)
Brand: Cell Biology Antibodies 18
SKU: CAB18393
Availability: OutOfStock

Antibody Name:	Anti-FZD8 Antibody
Antibody SKU:	CAB18393
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant protein of human FZD8.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, A-549, HeLa, Mouse liver, Rat liver

Immunogen:	Recombinant protein of human FZD8.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	8325
Uniprot:	Q9H461
Cellular Location:
Calculated MW:
Observed MW:	73kDa

Western blot - FZD8 Rabbit pAb (CAB18393)

Synonyms:	FZ-8, hFZ8, FZD8
Background:

UniProt Protein Function:	FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family.
UniProt Protein Details:	Protein type:Receptor, GPCR; Membrane protein, integral; GPCR, Fz/Smo family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: Golgi apparatus; integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; receptor binding; PDZ domain binding Biological Process: neuron differentiation; positive regulation of JNK activity; G-protein coupled receptor protein signaling pathway; T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
NCBI Summary:	This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9H461
NCBI GenInfo Identifier:	17433053
NCBI Gene ID:	8325
NCBI Accession:	Q9H461.1
UniProt Related Accession:	Q9H461
Molecular Weight:	73,300 Da
NCBI Full Name:	Frizzled-8
NCBI Synonym Full Names:	frizzled class receptor 8
NCBI Official Symbol:	FZD8
NCBI Official Synonym Symbols:	FZ-8; hFZ8
NCBI Protein Information:	frizzled-8; frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8
UniProt Protein Name:	Frizzled-8
Protein Family:	Frizzled
UniProt Gene Name:	FZD8
UniProt Entry Name:	FZD8_HUMAN