Metabolism Antibodies 3
Anti-FZD4 Antibody (CAB8161)
- SKU:
- CAB8161
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-FZD4 Antibody |
| Antibody SKU: | CAB8161 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-222 of human FZD4 (NP_036325.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse trachea, Mouse eye, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-222 of human FZD4 (NP_036325.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FGDE EERR CDPI RISM CQNL GYNV TKMP NLVG HELQ TDAE LQLT TFTP LIQY GCSS QLQF FLCS VYVP MCTE KINI PIGP CGGM CLSV KRRC EPVL KEFG FAWP ESLN CSKF PPQN DHNH MCME GPGD EEVP LPHK TPIQ PGEE CHSV GTNS DQYI WVKR SLNC VLKC GYDA GLYS RSAK EFTD IW |
| Gene ID: | 8322 |
| Uniprot: | Q9ULV1 |
| Cellular Location: | Cell membrane, Membrane, Multi-pass membrane protein |
| Calculated MW: | 59kDa |
| Observed MW: | 70kDa |
| Synonyms: | FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4 |
| Background: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. |
| UniProt Protein Function: | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| NCBI Summary: | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULV1 |
| NCBI GenInfo Identifier: | 62298045 |
| NCBI Gene ID: | 8322 |
| NCBI Accession: | Q9ULV1.2 |
| UniProt Secondary Accession: | Q9ULV1,Q14C97, Q6S9E4, A8K9Q3, |
| UniProt Related Accession: | Q9ULV1 |
| Molecular Weight: | 59,881 Da |
| NCBI Full Name: | Frizzled-4 |
| NCBI Synonym Full Names: | frizzled class receptor 4 |
| NCBI Official Symbol: | FZD4 |
| NCBI Official Synonym Symbols: | Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S |
| NCBI Protein Information: | frizzled-4 |
| UniProt Protein Name: | Frizzled-4 |
| UniProt Synonym Protein Names: | FzE4; CD_antigen: CD344 |
| UniProt Gene Name: | FZD4 |
 | Western blot - FZD4 Polyclonal Antibody (CAB8161) |
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