Metabolism Antibodies 1

Anti-FZD4 Antibody (CAB15113)

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SKU:
CAB15113
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-FZD4 Antibody
Antibody SKU:CAB15113
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 37-222 of human FZD4 (NP_036325.2).
Application:IF
Recommended Dilution:IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 37-222 of human FZD4 (NP_036325.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FGDE EERR CDPI RISM CQNL GYNV TKMP NLVG HELQ TDAE LQLT TFTP LIQY GCSS QLQF FLCS VYVP MCTE KINI PIGP CGGM CLSV KRRC EPVL KEFG FAWP ESLN CSKF PPQN DHNH MCME GPGD EEVP LPHK TPIQ PGEE CHSV GTNS DQYI WVKR SLNC VLKC GYDA GLYS RSAK EFTD IW
Gene ID:8322
Uniprot:Q9ULV1
Cellular Location:Cell membrane, Membrane, Multi-pass membrane protein
Calculated MW:59kDa
Observed MW:
Synonyms:FZD4, CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
Background:This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
UniProt Protein Function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
NCBI Summary:This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULV1
NCBI GenInfo Identifier:62298045
NCBI Gene ID:8322
NCBI Accession:Q9ULV1.2
UniProt Secondary Accession:Q9ULV1,Q14C97, Q6S9E4, A8K9Q3,
UniProt Related Accession:Q9ULV1
Molecular Weight:59,881 Da
NCBI Full Name:Frizzled-4
NCBI Synonym Full Names:frizzled class receptor 4
NCBI Official Symbol:FZD4  
NCBI Official Synonym Symbols:Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S  
NCBI Protein Information:frizzled-4
UniProt Protein Name:Frizzled-4
UniProt Synonym Protein Names:FzE4; CD_antigen: CD344
UniProt Gene Name:FZD4  
Anti-FZD4 Antibody (CAB15113)Immunofluorescence analysis of U2OS cells using FZD4 antibody (CAB15113) at dilution of 1:100. Blue: DAPI for nuclear staining.
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