Anti-FZD2 Antibody (CAB20421)
- SKU:
- CAB20421
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- Fz2
- Synonyms:
- fz-2
- Synonyms:
- fzE2
- Synonyms:
- hFz2
- Synonyms:
- OMOD2
Description
| Product Name: | FZD2 Rabbit pAb |
| Product Code: | CAB20421 |
| Size: | 50uL, 100uL |
| Synonyms: | Fz2, fz-2, fzE2, hFz2, OMOD2 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-247 of human FZD2 (NP_001457.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-247 of human FZD2 (NP_001457.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2535 |
| Uniprot: | Q14332 |
| Calculated MW: | 63kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | FZD2: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, Fz/Smo family; Receptor, GPCR Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: cytoplasm; focal adhesion; integral to membrane; plasma membrane Molecular Function: G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: neuron differentiation; positive regulation of cGMP metabolic process; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q14332 |
| NCBI GenInfo Identifier: | 17433019 |
| NCBI Gene ID: | 2535 |
| NCBI Accession: | Q14332.1 |
| UniProt Secondary Accession: | Q14332,Q0VG82 |
| UniProt Related Accession: | Q14332 |
| Molecular Weight: | 63,554 Da |
| NCBI Full Name: | Frizzled-2 |
| NCBI Synonym Full Names: | frizzled class receptor 2 |
| NCBI Official Symbol: | FZD2 |
| NCBI Official Synonym Symbols: | Fz2; fz-2; fzE2; hFz2 |
| NCBI Protein Information: | frizzled-2 |
| UniProt Protein Name: | Frizzled-2 |
| UniProt Synonym Protein Names: | FzE2 |
| Protein Family: | |
| UniProt Gene Name: | FZD2 |
| UniProt Entry Name: | FZD2_HUMAN |
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