Anti-FZD2 Antibody (CAB20421)

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SKU:
CAB20421
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Fz2
Synonyms:
fz-2
Synonyms:
fzE2
Synonyms:
hFz2
Synonyms:
OMOD2

Description

Product Name:FZD2 Rabbit pAb
Product Code:CAB20421
Size:50uL, 100uL
Synonyms:Fz2, fz-2, fzE2, hFz2, OMOD2
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-247 of human FZD2 (NP_001457.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-247 of human FZD2 (NP_001457.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2535
Uniprot:Q14332
Calculated MW:63kDa
Observed MW:Refer to figures
UniProt Protein Function:FZD2: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass; GPCR, Fz/Smo family; Receptor, GPCR Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: cytoplasm; focal adhesion; integral to membrane; plasma membrane Molecular Function: G-protein coupled receptor activity; PDZ domain binding; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: neuron differentiation; positive regulation of cGMP metabolic process; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
UniProt Protein Details:
NCBI Summary:This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
UniProt Code:Q14332
NCBI GenInfo Identifier:17433019
NCBI Gene ID:2535
NCBI Accession:Q14332.1
UniProt Secondary Accession:Q14332,Q0VG82
UniProt Related Accession:Q14332
Molecular Weight:63,554 Da
NCBI Full Name:Frizzled-2
NCBI Synonym Full Names:frizzled class receptor 2
NCBI Official Symbol:FZD2  
NCBI Official Synonym Symbols:Fz2; fz-2; fzE2; hFz2  
NCBI Protein Information:frizzled-2
UniProt Protein Name:Frizzled-2
UniProt Synonym Protein Names:FzE2
Protein Family:
UniProt Gene Name:FZD2  
UniProt Entry Name:FZD2_HUMAN
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