Cell Biology Antibodies 6
Anti-FYB Antibody (CAB15997)
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- SKU:
- CAB15997
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FYB Antibody |
| Antibody SKU: | CAB15997 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 678-829 of human FYB (NP_001456.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 678-829 of human FYB (NP_001456.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NEGS SFPA PPKQ LDMG DEVY DDVD TSDF PVSS AEMS QGTN VGKA KTEE KDLK KLKK QEKE EKDF RKKF KYDG EIRV LYST KVTT SITS KKWG TRDL QVKP GESL EVIQ TTDD TKVL CRNE EGKY GYVL RSYL ADND GEIY DDIA DGCI YDND |
| Gene ID: | 2533 |
| Uniprot: | O15117 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 85kDa/90kDa/91kDa |
| Observed MW: | 120KDa |
| Synonyms: | FYB, ADAP, PRO0823, SLAP-130, SLAP130, THC3 |
| Background: | The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLAP-130: an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: actin cytoskeleton; cytosol Molecular Function:protein binding; receptor binding Biological Process: NLS-bearing substrate import into nucleus; protein amino acid phosphorylation; signal transduction; T cell receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | O15117 |
| NCBI GenInfo Identifier: | 269849599 |
| NCBI Gene ID: | 2533 |
| NCBI Accession: | O15117.2 |
| UniProt Secondary Accession: | O15117,O00359, Q9NZI9, A8K2Y8, B4DLN2, E9PBV9, |
| UniProt Related Accession: | O15117 |
| Molecular Weight: | 91,651 Da |
| NCBI Full Name: | FYN-binding protein |
| NCBI Synonym Full Names: | FYN binding protein |
| NCBI Official Symbol: | FYB |
| NCBI Official Synonym Symbols: | ADAP; PRO0823; SLAP130; SLAP-130 |
| NCBI Protein Information: | FYN-binding protein |
| UniProt Protein Name: | FYN-binding protein |
| UniProt Synonym Protein Names: | Adhesion and degranulation promoting adaptor protein; ADAP; FYB-120/130; p120/p130; FYN-T-binding protein; SLAP-130; SLP-76-associated phosphoprotein |
| Protein Family: | FYN-binding protein |
| UniProt Gene Name: | FYB |
| UniProt Entry Name: | FYB_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using FYB antibody (CAB15997) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Western blot analysis of extracts of Mouse spleen, using FYB antibody (CAB15997) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
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