Cell Biology Antibodies 9

Anti-FXR2 Antibody (CAB4313)

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SKU:
CAB4313
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FXR2 Antibody
Antibody SKU:CAB4313
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_004851.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, MCF7, U-251MG, Mouse liver, Mouse heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_004851.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RRRT DEDR TVMD GGLE SDGP NMTE NGLE DESR PQRR NRSR RRRN RGNR TDGS ISGD RQPV TVAD YISR AESQ SRQR PPLE RTKP SEDS LSGQ KGDS VSKL P
Gene ID:9513
Uniprot:P51116
Cellular Location:Cytoplasm
Calculated MW:74kDa
Observed MW:104kDa
Synonyms:FXR2, FMR1L2, FXR2P
Background:The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome.
UniProt Protein Function:FXR2: RNA-binding protein. Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Belongs to the FMR1 family.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: polysome; membrane; cytoplasm; nucleus

Molecular Function:mRNA binding; identical protein binding; protein binding; RNA binding

Biological Process: negative regulation of translation

NCBI Summary:The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:P51116
NCBI GenInfo Identifier:90177782
NCBI Gene ID:9513
NCBI Accession:P51116.2
UniProt Secondary Accession:P51116,Q86V09, Q8WUM2, B2R9M2, D3DTQ1,
UniProt Related Accession:P51116
Molecular Weight:673
NCBI Full Name:Fragile X mental retardation syndrome-related protein 2
NCBI Synonym Full Names:fragile X mental retardation, autosomal homolog 2
NCBI Official Symbol:FXR2  
NCBI Official Synonym Symbols:FXR2P; FMR1L2  
NCBI Protein Information:fragile X mental retardation syndrome-related protein 2; fragile X-mental retardation 1-like 2
UniProt Protein Name:Fragile X mental retardation syndrome-related protein 2
Protein Family:Fragile X mental retardation syndrome-related protein
UniProt Gene Name:FXR2  
UniProt Entry Name:FXR2_HUMAN
Anti-FXR2 Antibody (CAB4313)Western blot analysis of extracts of various cell lines, using FXR2 antibody (CAB4313) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-FXR2 Antibody (CAB4313)Immunofluorescence analysis of U2OS cells using FXR2 antibody (CAB4313) at dilution of 1:100. Blue: DAPI for nuclear staining.
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