Cell Biology Antibodies 9
Anti-FUT6 Antibody (CAB3868)
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- SKU:
- CAB3868
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FUT6 Antibody |
| Antibody SKU: | CAB3868 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-359 of human FUT6 (NP_000141.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-359 of human FUT6 (NP_000141.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | WLEP WSGQ PAHP PLNL SAKT ELVA WAVS NWGP NSAR VRYY QSLQ AHLK VDVY GRSH KPLP QGTM METL SRYK FYLA FENS LHPD YITE KLWR NALE AWAV PVVL GPSR SNYE RFLP PDAF IHVD DFQS PKDL ARYL QELD KDHA RYLS YFRW RETL RPRS FSWA LAFC KACW KLQE ESRY QTRG IAAW FT |
| Gene ID: | 2528 |
| Uniprot: | P51993 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein |
| Calculated MW: | 41kDa/42kDa |
| Observed MW: | 42kDa |
| Synonyms: | FUT6, FCT3A, FT1A, Fuc-TVI, FucT-VI |
| Background: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | FUT6: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates. Belongs to the glycosyltransferase 10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.65; Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: Golgi apparatus; integral to membrane Molecular Function:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; alpha(1,3)-fucosyltransferase activity; fucosyltransferase activity Biological Process: protein amino acid glycosylation; L-fucose catabolic process Disease: Fucosyltransferase 6 Deficiency |
| NCBI Summary: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51993 |
| NCBI GenInfo Identifier: | 1730136 |
| NCBI Gene ID: | 2528 |
| NCBI Accession: | P51993.1 |
| UniProt Related Accession: | P51993 |
| Molecular Weight: | Observed Mol.Wt.: 45 kDa. Predicted Mol.Wt.: 42kDa. |
| NCBI Full Name: | Alpha-(1,3)-fucosyltransferase 6 |
| NCBI Synonym Full Names: | fucosyltransferase 6 |
| NCBI Official Symbol: | FUT6 |
| NCBI Official Synonym Symbols: | FT1A; FCT3A; Fuc-TVI; FucT-VI |
| NCBI Protein Information: | alpha-(1,3)-fucosyltransferase 6 |
| UniProt Protein Name: | Alpha-(1,3)-fucosyltransferase 6 |
| UniProt Synonym Protein Names: | Fucosyltransferase 6; Fucosyltransferase VI; Fuc-TVI; FucT-VI; Galactoside 3-L-fucosyltransferase |
| Protein Family: | Fucosyltransferase |
| UniProt Gene Name: | FUT6 |
| UniProt Entry Name: | FUT6_HUMAN |
 | Western blot analysis of extracts of SW480 cells, using FUT6 antibody (CAB3868) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver using FUT6 antibody (CAB3868) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using FUT6 antibody (CAB3868) at dilution of 1:100 (40x lens). |
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