Cell Biology Antibodies 9
Anti-FUT2 Antibody (CAB5721)
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- SKU:
- CAB5721
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FUT2 Antibody |
| Antibody SKU: | CAB5721 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-150 of human FUT2 (NP_001091107.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, K-562, mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-150 of human FUT2 (NP_001091107.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QQRL AKIQ AMWE LPVQ IPVL ASTS KALG PSQL RGMW TINA IGRL GNQM GEYA TLYA LAKM NGRP AFIP AQMH STLA PIFR ITLP VLHS ATAS RIPW QNYH LNDW MEEE YRHI PGEY VRFT GY |
| Gene ID: | 2524 |
| Uniprot: | Q10981 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein |
| Calculated MW: | 37kDa/39kDa |
| Observed MW: | 37kDa |
| Synonyms: | FUT2, B12QTL1, SE, SEC2, Se2, sej |
| Background: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). |
| NCBI Summary: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q10981 |
| NCBI GenInfo Identifier: | 1730125 |
| NCBI Gene ID: | 2524 |
| NCBI Accession: | Q10981.1 |
| UniProt Secondary Accession: | Q10981,Q0VAG5, Q14338, Q5D0G2, |
| UniProt Related Accession: | Q10981 |
| Molecular Weight: | 39 kDa |
| NCBI Full Name: | Galactoside 2-alpha-L-fucosyltransferase 2 |
| NCBI Synonym Full Names: | fucosyltransferase 2 |
| NCBI Official Symbol: | FUT2 |
| NCBI Official Synonym Symbols: | SE; Se2; sej; SEC2; B12QTL1 |
| NCBI Protein Information: | galactoside 2-alpha-L-fucosyltransferase 2 |
| UniProt Protein Name: | Galactoside 2-alpha-L-fucosyltransferase 2 |
| UniProt Synonym Protein Names: | Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; SE2; Secretor blood group alpha-2-fucosyltransferase; Secretor factor; Se |
| Protein Family: | Fucosyltransferase |
| UniProt Gene Name: | FUT2 |
 | Western blot analysis of extracts of HT-29 cells, using FUT2 antibody (CAB5721) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Western blot analysis of extracts of various cell lines, using FUT2 antibody (CAB5721) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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