Epigenetics & Nuclear Signaling Antibodies 4

Anti-FTSJ1 Antibody (CAB7967)

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SKU:
CAB7967
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:FTSJ1 Rabbit Polyclonal Antibody
Antibody SKU:CAB7967
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-329 of human FTSJ1 (NP_036412.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-1080
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-329 of human FTSJ1 (NP_036412.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LQVF FSSV LCAK PRSS RNSS IEAF AVCQ GYDP PEGF IPDL SKPL LDHS YDPD FNQL DGPT RIIV PFVT CGDL SSYD SDRS YPLD LEGG SEYK YTPP TQPP ISPP YQEA CTLK RKGQ LAKE IRPQ DCPI SRVD TFPQ PLAA PQCH TLLA PEME DNEM SCSP
Gene ID:24140
Uniprot:Q9UET6
Cellular Location:Cytoplasm
Calculated MW:35kDa/36kDa
Observed MW:26kDa
Synonyms:FTSJ1, CDLIV, JM23, MRX44, MRX9, SPB1, TRMT7
Background:This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.1.1.205; Methyltransferase

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm

Molecular Function:tRNA methyltransferase activity

Biological Process: tRNA methylation

Disease: Mental Retardation, X-linked 9

NCBI Summary:This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Code:Q9UET6
NCBI GenInfo Identifier:12643879
NCBI Gene ID:24140
NCBI Accession:Q9UET6.2
UniProt Secondary Accession:Q9UET6,O75670, B2RCJ0,
UniProt Related Accession:Q9UET6
Molecular Weight:35,867 Da
NCBI Full Name:Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
NCBI Synonym Full Names:FtsJ RNA methyltransferase homolog 1 (E. coli)
NCBI Official Symbol:FTSJ1  
NCBI Official Synonym Symbols:JM23; MRX9; SPB1; CDLIV; MRX44; TRMT7  
NCBI Protein Information:putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
UniProt Protein Name:Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
UniProt Synonym Protein Names:2'-O-ribose RNA methyltransferase TRM7 homolog
UniProt Gene Name:FTSJ1  
UniProt Entry Name:TRM7_HUMAN
Anti-FTSJ1 Polyclonal Antibody (CAB7967)Western blot analysis of extracts of HT-1080 cells, using FTSJ1 Antibody (CAB7967) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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