Description
| Antibody Name: | FTSJ1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7967 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-329 of human FTSJ1 (NP_036412.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-1080 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-329 of human FTSJ1 (NP_036412.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQVF FSSV LCAK PRSS RNSS IEAF AVCQ GYDP PEGF IPDL SKPL LDHS YDPD FNQL DGPT RIIV PFVT CGDL SSYD SDRS YPLD LEGG SEYK YTPP TQPP ISPP YQEA CTLK RKGQ LAKE IRPQ DCPI SRVD TFPQ PLAA PQCH TLLA PEME DNEM SCSP |
| Gene ID: | 24140 |
| Uniprot: | Q9UET6 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 35kDa/36kDa |
| Observed MW: | 26kDa |
| Synonyms: | FTSJ1, CDLIV, JM23, MRX44, MRX9, SPB1, TRMT7 |
| Background: | This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FTSJ1: Defects in FTSJ1 are the cause of mental retardation X- linked type 44 (MRX44). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the methyltransferase superfamily. RlmE family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.1.1.205; Methyltransferase Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytoplasm Molecular Function:tRNA methyltransferase activity Biological Process: tRNA methylation Disease: Mental Retardation, X-linked 9 |
| NCBI Summary: | This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9UET6 |
| NCBI GenInfo Identifier: | 12643879 |
| NCBI Gene ID: | 24140 |
| NCBI Accession: | Q9UET6.2 |
| UniProt Secondary Accession: | Q9UET6,O75670, B2RCJ0, |
| UniProt Related Accession: | Q9UET6 |
| Molecular Weight: | 35,867 Da |
| NCBI Full Name: | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase |
| NCBI Synonym Full Names: | FtsJ RNA methyltransferase homolog 1 (E. coli) |
| NCBI Official Symbol: | FTSJ1 |
| NCBI Official Synonym Symbols: | JM23; MRX9; SPB1; CDLIV; MRX44; TRMT7 |
| NCBI Protein Information: | putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase |
| UniProt Protein Name: | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase |
| UniProt Synonym Protein Names: | 2'-O-ribose RNA methyltransferase TRM7 homolog |
| UniProt Gene Name: | FTSJ1 |
| UniProt Entry Name: | TRM7_HUMAN |
 | Western blot analysis of extracts of HT-1080 cells, using FTSJ1 Antibody (CAB7967) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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