Cell Biology Antibodies 7

Anti-FTL Antibody (CAB1768)

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SKU:
CAB1768
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FTL Antibody
Antibody SKU:CAB1768
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human FTL (NP_000137.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Reactivity:Human, Mouse
Positive Samples:293T, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human FTL (NP_000137.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSQ IRQN YSTD VEAA VNSL VNLY LQAS YTYL SLGF YFDR DDVA LEGV SHFF RELA EEKR EGYE RLLK MQNQ RGGR ALFQ DIKK PAED EWGK TPDA MKAA MALE KKLN QALL DLHA LGSA RTDP HLCD FLET HFLD EEVK LIKK MGDH LTNL HRLG GPEA GLGE YLFE RLTL KHD
Gene ID:2512
Uniprot:P02792
Cellular Location:
Calculated MW:20kDa
Observed MW:20KDa
Synonyms:FTL, LFTD, NBIA3
Background:This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
UniProt Protein Function:FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
UniProt Protein Details:

Protein type:Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: ferritin complex; membrane; cytosol

Molecular Function:identical protein binding; protein binding; ferric iron binding; iron ion binding

Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport

Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

NCBI Summary:This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Code:P02792
NCBI GenInfo Identifier:120523
NCBI Gene ID:2512
NCBI Accession:P02792.2
UniProt Secondary Accession:P02792,Q6IBT7, Q7Z2W1, Q86WI9, Q8WU07, Q96AU9, Q96CU0 Q9BTZ8, B2R4B9,
UniProt Related Accession:P02792
Molecular Weight:440 kDa
NCBI Full Name:Ferritin light chain
NCBI Synonym Full Names:ferritin, light polypeptide
NCBI Official Symbol:FTL  
NCBI Official Synonym Symbols:LFTD; NBIA3  
NCBI Protein Information:ferritin light chain; ferritin L-chain; ferritin L subunit; ferritin light polypeptide-like 3
UniProt Protein Name:Ferritin light chain
Protein Family:Ferritin
UniProt Gene Name:FTL  
UniProt Entry Name:FRIL_HUMAN
Anti-FTL Antibody (CAB1768)Western blot analysis of extracts of various cell lines, using FTL Rabbit pAb (CAB1768) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
Anti-FTL Antibody (CAB1768)Immunohistochemistry of paraffin-embedded human amygdalitis using FTL antibody (CAB1768) at dilution of 1:100 (40x lens).
Anti-FTL Antibody (CAB1768)Immunofluorescence analysis of L929 cells using FTL Rabbit pAb (CAB1768) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-FTL Antibody (CAB1768)Immunofluorescence analysis of U-2 OS cells using FTL Rabbit pAb (CAB1768) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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