Metabolism Antibodies 3

Anti-FTCD Antibody (CAB9484)

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SKU:
CAB9484
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-FTCD Antibody
Antibody SKU:CAB9484
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 412-541 of human FTCD (NP_006648.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 412-541 of human FTCD (NP_006648.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DAEA FTAY LEAM RLPK NTPE EKDR RTAA LQEG LRRA VSVP LTLA ETVA SLWP ALQE LARC GNLA CRSD LQVA AKAL EMGV FGAY FNVL INLR DITD EAFK DQIH HRVS SLLQ EAKT QAAL VLDC LETR QE
Gene ID:10841
Uniprot:O95954
Cellular Location:Cytoplasm, Golgi apparatus, centriole, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:16kDa/52kDa/58kDa/61kDa
Observed MW:59kDa
Synonyms:FTCD, LCHC1
Background:The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:FTCD: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency (FIGLU-URIA); also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - histidine; Lyase; Methyltransferase; EC 4.3.1.4; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.5

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: centriole; Golgi apparatus; cytoplasm; cytosol

Molecular Function:formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity; folic acid binding

Biological Process: folic acid and derivative metabolic process; cytoskeleton organization and biogenesis; histidine catabolic process to glutamate and formamide; histidine catabolic process; histidine catabolic process to glutamate and formate

Disease: Formiminotransferase Deficiency

NCBI Summary:The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
UniProt Code:O95954
NCBI GenInfo Identifier:8134464
NCBI Gene ID:10841
NCBI Accession:O95954.2
UniProt Secondary Accession:O95954,Q86V03, Q9HCT4, Q9HCT5, Q9HCT6, Q9UHJ2, B9EGD0
UniProt Related Accession:O95954
Molecular Weight:16,503 Da
NCBI Full Name:Formimidoyltransferase-cyclodeaminase
NCBI Synonym Full Names:formimidoyltransferase cyclodeaminase
NCBI Official Symbol:FTCD  
NCBI Official Synonym Symbols:LCHC1  
NCBI Protein Information:formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase
UniProt Protein Name:Formimidoyltransferase-cyclodeaminase
UniProt Synonym Protein Names:Formiminotransferase-cyclodeaminase; FTCD; LCHC1Including the following 2 domains:Glutamate formimidoyltransferase (EC:2.1.2.5)Alternative name(s):Glutamate formiminotransferase; Glutamate formyltransferase
Protein Family:Formimidoyltransferase-cyclodeaminase
UniProt Gene Name:FTCD  
UniProt Entry Name:FTCD_HUMAN
Anti-FTCD Polyclonal Antibody (CAB9484)Western blot analysis of extracts of various cell lines, using FTCD antibody (CAB9484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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