Cell Biology Antibodies 1

Anti-FSTL3 Antibody (CAB10279)

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SKU:
CAB10279
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-FSTL3 Antibody
Antibody SKU:CAB10279
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, DU145, MCF7, SKOV3, Mouse lung, Mouse kidney, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_005851.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGSG NPAP GGVC WLQQ GQEA TCSL VLQT DVTR AECC ASGN IDTA WSNL THPG NKIN LLGF LGLV HCLP CKDS CDGV ECGP GKAC RMLG GRPR CECA PDCS GLPA RLQV CGSD GATY RDEC ELRA ARCR GHPD LSVM YRGR CRKS CEHV VCPR PQSC VVDQ TGSA HCVV CRAA PCPV PSSP GQEL CGNN NVTY ISSC HMRQ ATCF LGRS IGVR HAGS CAGT PEEP PGGE SAEE EENF V
Gene ID:10272
Uniprot:O95633
Cellular Location:Nucleus, Secreted
Calculated MW:24kDa/27kDa
Observed MW:27kDa
Synonyms:FSTL3, FLRG, FSRP
Background:Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.
UniProt Protein Function:FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular region; extracellular space; nucleoplasm; nucleus

Molecular Function:activin binding; fibronectin binding; protein binding

Biological Process: hemopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; negative regulation of BMP signaling pathway; negative regulation of osteoclast differentiation; positive regulation of cell-cell adhesion; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter

NCBI Summary:Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:O95633
NCBI GenInfo Identifier:23821565
NCBI Gene ID:10272
NCBI Accession:O95633.1
UniProt Secondary Accession:O95633,A8K7E3,
UniProt Related Accession:O95633
Molecular Weight:28kDa
NCBI Full Name:Follistatin-related protein 3
NCBI Synonym Full Names:follistatin like 3
NCBI Official Symbol:FSTL3  
NCBI Official Synonym Symbols:FLRG; FSRP  
NCBI Protein Information:follistatin-related protein 3
UniProt Protein Name:Follistatin-related protein 3
UniProt Synonym Protein Names:Follistatin-like protein 3; Follistatin-related gene protein
Protein Family:Follistatin-related protein
UniProt Gene Name:FSTL3  
Anti-FSTL3 Antibody (CAB10279)Western blot analysis of extracts of various cell lines, using FSTL3 antibody (CAB10279) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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