Cell Biology Antibodies 8

Anti-FST Antibody (CAB2936)

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SKU:
CAB2936
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FST Antibody
Antibody SKU:CAB2936
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human FST
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2
Immunogen:A synthetic peptide of human FST
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10468
Uniprot:P19883
Cellular Location:Secreted
Calculated MW:34kDa/38kDa
Observed MW:38kDa
Synonyms:FST, FS
Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
UniProt Protein Function:FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; extracellular region; nucleus

Molecular Function:heparan sulfate proteoglycan binding; signal transducer activity; protein binding; activin binding

Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; skeletal development; female gonad development; odontogenesis of dentine-containing teeth

Disease: Polycystic Ovary Syndrome 1

NCBI Summary:Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
UniProt Code:P19883
NCBI GenInfo Identifier:23831079
NCBI Gene ID:10468
NCBI Accession:P19883.2
UniProt Secondary Accession:P19883,Q9BTH0, B5BU94,
UniProt Related Accession:P19883
Molecular Weight:34,803 Da
NCBI Full Name:Follistatin
NCBI Synonym Full Names:follistatin
NCBI Official Symbol:FST  
NCBI Official Synonym Symbols:FS  
NCBI Protein Information:follistatin; activin-binding protein; follistatin isoform FST317
UniProt Protein Name:Follistatin
UniProt Synonym Protein Names:Activin-binding protein
Protein Family:Follistatin
UniProt Gene Name:FST  
UniProt Entry Name:FST_HUMAN
Anti-FST Antibody (CAB2936)Western blot analysis of extracts of HepG2 cells, using FST antibody (CAB2936). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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