Cell Biology Antibodies 8

Anti-FSHR Antibody (CAB3172)

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SKU:
CAB3172
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FSHR Antibody
Antibody SKU:CAB3172
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human FSHR
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:SW620
Immunogen:Recombinant protein of human FSHR
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2492
Uniprot:P23945
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:71kDa/75kDa/78kDa/81kDa
Observed MW:72kDa
Synonyms:FSHR, FSHR1, FSHRO, LGR1, ODG1
Background:The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p21-p16

Cellular Component: plasma membrane; integral to membrane

Molecular Function:protein binding; follicle-stimulating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; gonad development; follicle-stimulating hormone signaling pathway; male gonad development; female gamete generation; spermatogenesis; female gonad development

Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

NCBI Summary:The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Code:P23945
NCBI GenInfo Identifier:311033420
NCBI Gene ID:2492
NCBI Accession:P23945.3
UniProt Secondary Accession:P23945,Q05AH0, Q16225, Q4QRJ3, Q4ZFZ2, Q53RW2, A8K947 G5CBS7, G5E967, J3KQ00,
UniProt Related Accession:P23945
Molecular Weight:695
NCBI Full Name:Follicle-stimulating hormone receptor
NCBI Synonym Full Names:follicle stimulating hormone receptor
NCBI Official Symbol:FSHR  
NCBI Official Synonym Symbols:LGR1; ODG1; FSHRO  
NCBI Protein Information:follicle-stimulating hormone receptor; FSH receptor; follitropin receptor
UniProt Protein Name:Follicle-stimulating hormone receptor
UniProt Synonym Protein Names:Follitropin receptor
Protein Family:Follicle-stimulating hormone receptor
UniProt Gene Name:FSHR  
UniProt Entry Name:FSHR_HUMAN
Anti-FSHR Antibody (CAB3172)Western blot analysis of extracts of SW620 cells, using FSHR antibody (CAB3172). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-FSHR Antibody (CAB3172)Immunohistochemistry of paraffin-embedded rat testis using FSHR antibody (CAB3172) at dilution of 1:100 (40x lens).
Anti-FSHR Antibody (CAB3172)Immunohistochemistry of paraffin-embedded rat ovary using FSHR antibody (CAB3172) at dilution of 1:100 (40x lens).
Anti-FSHR Antibody (CAB3172)Immunofluorescence analysis of HeLa cells using FSHR antibody (CAB3172) at dilution of 1:100. Blue: DAPI for nuclear staining.
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