Cell Biology Antibodies 11
Anti-FRK Antibody (CAB7556)
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- SKU:
- CAB7556
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-FRK Antibody |
| Antibody SKU: | CAB7556 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human FRK (NP_002022.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, MCF7, SW620, NCI-H460, HepG2, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human FRK (NP_002022.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSNI CQRL WEYL EPYL PCLS TEAD KSTV IENP GALC SPQS QRHG HYFV ALFD YQAR TAED LSFR AGDK LQVL DTLH EGWW FARH LEKR RDGS SQQL QGYI PSNY VAED RSLQ AEPW FFGA IGRS DAEK QLLY SENK TGSF LIRE SESQ KGEF SLSV LDGA VVKH YRIK RLDE GGFF LTRR RIFS TLNE FVSH YTKT SDGL CVKL GKPC LKIQ VPAP FDLS |
| Gene ID: | 2444 |
| Uniprot: | P42685 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 41kDa/58kDa |
| Observed MW: | 58kDa |
| Synonyms: | FRK, GTK, PTK5, RAK |
| Background: | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. |
| UniProt Protein Function: | FRK: a tyrosine kinase of the Src family. Expressed in cell lines derived from tissues of lymphoid, brain, breast, colon and bladder origin. A nuclear protein that may function during G1 and S phase of the cell cycle to suppress growth. |
| UniProt Protein Details: | Protein type:EC 2.7.10.2; Tumor suppressor; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Src family Chromosomal Location of Human Ortholog: 6q21-q22.3 Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; intracellular; intracellular membrane-bound organelle; nucleus Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; innate immune response; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42685 |
| NCBI GenInfo Identifier: | 1169745 |
| NCBI Gene ID: | 2444 |
| NCBI Accession: | P42685.1 |
| UniProt Secondary Accession: | P42685,Q13128, Q9NTR5, B4DY49, |
| UniProt Related Accession: | P42685 |
| Molecular Weight: | 41,980 Da |
| NCBI Full Name: | Tyrosine-protein kinase FRK |
| NCBI Synonym Full Names: | fyn related Src family tyrosine kinase |
| NCBI Official Symbol: | FRK |
| NCBI Official Synonym Symbols: | GTK; RAK; PTK5 |
| NCBI Protein Information: | tyrosine-protein kinase FRK |
| UniProt Protein Name: | Tyrosine-protein kinase FRK |
| UniProt Synonym Protein Names: | FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5 |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | FRK |
| UniProt Entry Name: | FRK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FRK antibody (CAB7556) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using FRK antibody (CAB7556). Blue: DAPI for nuclear staining. |
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