| UniProt Protein Function: | FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Motility/polarity/chemotaxis; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: endosome; plasma membrane Molecular Function: N-formyl peptide receptor activity; protein binding; receptor activity Biological Process: activation of MAPK activity; cell motility; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); nitric oxide mediated signal transduction; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010] |
| UniProt Code: | P21462 |
| NCBI GenInfo Identifier: | 288558848 |
| NCBI Gene ID: | 2357 |
| NCBI Accession: | P21462.3 |
| UniProt Secondary Accession: | P21462,Q14939, Q7Z6A4, Q86U52, Q9NS48 |
| UniProt Related Accession: | P21462 |
| Molecular Weight: | 38,446 Da |
| NCBI Full Name: | fMet-Leu-Phe receptor |
| NCBI Synonym Full Names: | formyl peptide receptor 1 |
| NCBI Official Symbol: | FPR1 |
| NCBI Official Synonym Symbols: | FPR; FMLP |
| NCBI Protein Information: | fMet-Leu-Phe receptor |
| UniProt Protein Name: | fMet-Leu-Phe receptor |
| UniProt Synonym Protein Names: | N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FPR1 |
| UniProt Entry Name: | FPR1_HUMAN |
