Cell Biology Antibodies 1

Anti-FOXRED1 Antibody (CAB10369)

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SKU:
CAB10369
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-FOXRED1 Antibody
Antibody SKU:CAB10369
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 307-486 of human FOXRED1 (NP_060017.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, A-549, K-562, Mouse kidney, Mouse lung, Rat kidney, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 307-486 of human FOXRED1 (NP_060017.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GPPG TLQG TKLP VEPR KRYV YVWH CPQG PGLE TPLV ADTS GAYF RREG LGSN YLGG RSPT EQEE PDPA NLEV DHDF FQDK VWPH LALR VPAF ETLK VQSA WAGY YDYN TFDQ NGVV GPHP LVVN MYFA TGFS GHGL QQAP GIGR AVAE MVLK GRFQ TIDL SPFL FTRF YLGE KIQE NNII
Gene ID:55572
Uniprot:Q96CU9
Cellular Location:Mitochondrion inner membrane, Single-pass membrane protein
Calculated MW:30kDa/52kDa/53kDa
Observed MW:58kDa
Synonyms:FOXRED1, FP634, H17
Background:This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene.
UniProt Protein Function:FOXRED1: Defects in FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion

Biological Process: mitochondrial respiratory chain complex I assembly

Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency

NCBI Summary:This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q96CU9
NCBI GenInfo Identifier:124007188
NCBI Gene ID:55572
NCBI Accession:Q96CU9.2
UniProt Secondary Accession:Q96CU9,Q71MG0, Q9BU39, Q9UKY9, B3KN84, B4DHU2,
UniProt Related Accession:Q96CU9
Molecular Weight:52,104 Da
NCBI Full Name:FAD-dependent oxidoreductase domain-containing protein 1
NCBI Synonym Full Names:FAD dependent oxidoreductase domain containing 1
NCBI Official Symbol:FOXRED1  
NCBI Official Synonym Symbols:H17; FP634  
NCBI Protein Information:FAD-dependent oxidoreductase domain-containing protein 1
UniProt Protein Name:FAD-dependent oxidoreductase domain-containing protein 1
Protein Family:FAD-dependent oxidoreductase domain-containing protein
UniProt Gene Name:FOXRED1  
UniProt Entry Name:FXRD1_HUMAN
Anti-FOXRED1 Antibody (CAB10369)Western blot analysis of extracts of various cell lines, using FOXRED1 antibody (CAB10369) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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