Epigenetics & Nuclear Signaling Antibodies 4
Anti-FOXP3 Antibody (CAB8024)
- SKU:
- CAB8024
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Antibody Name: | FOXP3 Rabbit Polyclonal Antibody |
Antibody SKU: | CAB8024 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human FOXP3 (NP_054728.2). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Rat |
Positive Samples: | Rat pancreas |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human FOXP3 (NP_054728.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 50943 |
Uniprot: | Q9BZS1 |
Cellular Location: | Cytoplasm, Nucleus |
Calculated MW: | 43kDa/44kDa/47kDa/49kDa |
Observed MW: | 47kDa |
Synonyms: | FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID |
Background: | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
UniProt Protein Function: | FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding; Cell cycle regulation Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytoplasm; nucleus Molecular Function:histone acetyltransferase binding; histone deacetylase binding; NFAT protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T cell anergy; response to virus; T cell activation Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked |
NCBI Summary: | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BZS1 |
NCBI GenInfo Identifier: | 14548061 |
NCBI Gene ID: | 50943 |
NCBI Accession: | Q9BZS1.1 |
UniProt Secondary Accession: | Q9BZS1,O60827, Q14DD8, Q4ZH51, A5HJT1, B7ZLG0, B9UN80 |
UniProt Related Accession: | Q9BZS1 |
Molecular Weight: | 44,407 Da |
NCBI Full Name: | Forkhead box protein P3 |
NCBI Synonym Full Names: | forkhead box P3 |
NCBI Official Symbol: | FOXP3 |
NCBI Official Synonym Symbols: | JM2; AIID; IPEX; PIDX; XPID; DIETER |
NCBI Protein Information: | forkhead box protein P3 |
UniProt Protein Name: | Forkhead box protein P3 |
UniProt Synonym Protein Names: | Scurfin |
Protein Family: | Forkhead box protein |
UniProt Gene Name: | FOXP3 |
UniProt Entry Name: | FOXP3_HUMAN |