Epigenetics & Nuclear Signaling Antibodies 2
Anti-FOXP3 Antibody (CAB5706)
- SKU:
- CAB5706
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-FOXP3 Antibody |
| Antibody SKU: | CAB5706 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human FOXP3 (NP_001107849.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse pancreas, Mouse brain, Mouse thymus, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human FOXP3 (NP_001107849.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LKHC QADH LLDE KGRA QCLL QREM VQSL EQQL VLEK EKLS AMQA HLAG KMAL TKAS SVAS SDKG SCCI VAAG SQGP VVPA WSGP REAP DSLF AVRR HLWG SHGN STFP EFLH NMDY FKFH N |
| Gene ID: | 50943 |
| Uniprot: | Q9BZS1 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 43kDa/44kDa/47kDa/49kDa |
| Observed MW: | 47kDa |
| Synonyms: | FOXP3, AIID, DIETER, IPEX, JM2, PIDX, XPID |
| Background: | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding; Cell cycle regulation Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytoplasm; nucleus Molecular Function:histone acetyltransferase binding; histone deacetylase binding; NFAT protein binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; negative regulation of cell proliferation; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of T cell anergy; response to virus; T cell activation Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked |
| NCBI Summary: | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZS1 |
| NCBI GenInfo Identifier: | 14548061 |
| NCBI Gene ID: | 50943 |
| NCBI Accession: | Q9BZS1.1 |
| UniProt Secondary Accession: | Q9BZS1,O60827, Q14DD8, Q4ZH51, A5HJT1, B7ZLG0, B9UN80 |
| UniProt Related Accession: | Q9BZS1 |
| Molecular Weight: | 44,407 Da |
| NCBI Full Name: | Forkhead box protein P3 |
| NCBI Synonym Full Names: | forkhead box P3 |
| NCBI Official Symbol: | FOXP3 |
| NCBI Official Synonym Symbols: | JM2; AIID; IPEX; PIDX; XPID; DIETER |
| NCBI Protein Information: | forkhead box protein P3 |
| UniProt Protein Name: | Forkhead box protein P3 |
| UniProt Synonym Protein Names: | Scurfin |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXP3 |
| UniProt Entry Name: | FOXP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FOXP3 antibody (CAB5706) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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